RepurposeDB | Reference Database of Drug Repositioning Investigations

Right drug in right dose for right patient at right time via right route is defined as one of the promising outcome of personalized, multi-omic medicine. Systematic drug repositioning enables the translation of insights from computational analyses coupled with laboratory based or experimental findings to bench side in a shorter span of time. From the first report of drug repositioning in early 1950s till 2016, more than 250 successful reports have been published in the literature. We analyzed the repertoire of such cases reported and derived a molecular code for drug repositioning. The analyses of the data in the format of drugs, primary indications and secondary indications reveal molecular preferences; ligand classes, functional roles and pathways were drug repositioning was successful. We envisage our first report on global analyses of successful drug repositioning space and RepurposeDB could help to develop predictive models of drug repositioning and can have major influence in personalized drug repositioning, an emerging therapeutic area in data-driven, individualized medicine.

Explore RepurposeDB

Repositioned Drugs

Explore repositioned drug cataloged in RepurposeDB

Browse Drugs »


Primary and secondary indications of drugs cataloged in RepurposeDB

Browse Diseases »


If you have a new indication to existing drug, contribute to RepurposeDB

Submit Data »


If you'd like access to the RepurposeDB source data, you can find it here

Source Data »

Who We Are

Dudley lab logo



If you use RepurposeDB or the associated data, please cite us!

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.

Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY