Rx00002 - Acetylcysteine


Name:
Acetylcysteine
Rx ID:
Rx00002
Validation Level:
Phenomic Similarity:
0.511
Reference ID:
DB06151
Primary Indications:
Mucolytic; paracetamol overdose; acetaminophen overdose
Orphan Indications:
Acute liver failure
Rare Indications:
Hepatotoxicity; hepatic injury; abnormal mucous secretions; viscid mucous secretions; inspissated mucous secretions; chronic bronchopulmonary disease; tuberculosis; bronchiectasis; primary amyloidosis of the lung; cystic fibrosis; Tracheostom
Common Indications:
Abnormal mucous secretions; viscid mucous secretions; inspissated mucous secretions; chronic bronchopulmonary disease; chronic emphysema; emphysema with bronchitis; chronic asthmatic bronchitis; Acute bronchopulmonary disease; pneumonia; bronchitis; tracheobronchitis; anesthesia; Post-traumatic chest conditions; Atelectasis; mucous obstruction; bronchograms; bronchospirometry; bronchial wedge catheterization
Pathways:
Metabolic disorders of biological oxidation enzymes; Signal Transduction; CREB phosphorylation through the activation of Ras; Hepatitis C - Homo sapiens (human); Osteopontin Signaling; Post NMDA recep ...Click to show more
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00002
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
acetaminophen overdose acute liver failure 188 552 7101 193.524 0 0.0
paracetamol overdose acute liver failure 188 552 7101 193.524 0 0.0

Chemical, Pharmacological and Biological Annotations


ATC Code:
No ATC code annotated in DrugBank
Brands:
Fluimucil; Lysox; Mucolysin (Zambon); Mucomyst (Mead Johnson); Parvolex
Categories:
Antiviral Agents; Free Radical Scavengers; Expectorants
ChEBI ID:
28939
PubChem ID:
12035
KEGG Drug ID:
D00221
SMILE:
CC(=O)N[C@@H](CS)C(O)=O
InChI:
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids and Derivatives
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
Acetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
Pharmacodynamics:
Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose. It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine ...
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Description:
Acetylcysteine (also known as N-acetylcysteine or N-acetyl-L-cysteine or NAC) is primarily used as a mucolytic agent and in the management of acetaminophen poisoning. It is a derivative of cysteine with an acetyl group attached to the amin...
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Mechanism:
Acetylcysteine protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. It does this by producing the glutathione precursor L-cysteine. Glutathione is required to inac...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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