Rx00003 - Acetylsalicylic Acid


Name:
Acetylsalicylic Acid
Rx ID:
Rx00003
Validation Level:
Reference ID:
DB00945
Primary Indications:
Analgesic
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Antiplatelet
Drug Interactions:
Acenocoumarol; Acetazolamide; Acetohexamide; Anisindione; Azilsartan medoxomil; Betamethasone; Chlorpropamide; Cortisone acetate; Dexamethasone; Diclofenamide; ...
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Food Interactions:
Avoid alcohol, alcohol appears to cause a 50 to 100% increases in ASA serum levels. Take with a full glass of water. Take with food to reduce gastric irritation.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00003
Primary Indication
Secondary Indication

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Chemical, Pharmacological and Biological Annotations


ATC Code:
A01AD05; B01AC06 N02BA01;
Brands:
Acenterine; Acetophen (Merck); Adiro; Aspergum; Aspro; Bayer Aspirin (Bayer HealthCare LLC.); Easprin; Empirin; Nu-seals; Rhodine; Rhonal; Solprin; Solprin acid; St. Joseph Aspirin for Adults; Tasprin
Categories:
Fibrinolytic Agents; Platelet Aggregation Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Antipyretics; Salicylates
ChEBI ID:
15365
PubChem ID:
2244
KEGG Drug ID:
D00109
SMILE:
CC(=O)OC1=CC=CC=C1C(O)=O
InChI:
1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
Classification:
Kingdom:
Organic Compounds
Superclass:
Benzenoids
Class:
Benzene and Substituted Derivatives
Subclass:
Phenol Esters
Indication:
For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylit...
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Pharmacodynamics:
Acetylsalicylic acid is an analgesic, antipyretic, antirheumatic, and anti-inflammatory agent. Acetylsalicylic acid's mode of action as an antiinflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostag...
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Description:
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins....
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Mechanism:
The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Acetylsalicylic acid ...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
-
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Ready biodegradable
Rat acute toxicity:
2.6386 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org