Rx00005 - Adenosine


Name:
Adenosine
Rx ID:
Rx00005
Validation Level:
Phenomic Similarity:
0.709
Reference ID:
DB00640
Primary Indications:
Brain tumor
Orphan Indications:
Paroxysmal supraventricular tachycardia; Wolff-Parkinson-White syndrome
Rare Indications:
No annotated rare indications.
Common Indications:
No annotated common indications.
Pathways:
Class A/1 (Rhodopsin-like receptors); cAMP signaling pathway - Homo sapiens (human); G alpha (s) signalling events; cGMP-PKG signaling pathway - Homo sapiens (human); G alpha (i) signalling events; Ad ...Click to show more
Drug Interactions:
Aminophylline; Caffeine; Dipyridamole; Dyphylline; Oxtriphylline Theophylline;
Food Interactions:
Avoid caffeine containing foods and drinks.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00005
Primary Indication
Secondary Indication

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Chemical, Pharmacological and Biological Annotations


ATC Code:
C01EB10
Brands:
Adenocor (Sanofi-Aventis); Adenoject (Sun); Adenoz (Celon); Adenozer (Purzer); Adesin (Dae Han New Pharm); Adrekar (Sanofi-Aventis); Atépadène (Mayoly-Spindler); Cardimax (AC Farma); Cardiovert (Sanofi-Aventis); Krenosin (Sanofi-Aventis); Osiden (Square); Pisdeno (Pisa)
Categories:
Anti-Arrhythmia Agents; Analgesics; Vasodilator Agents; Cardiovascular Agents
ChEBI ID:
16335
PubChem ID:
60961
KEGG Drug ID:
D00045
SMILE:
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1
InChI:
1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Organooxygen Compounds
Class:
Carbohydrates and Carbohydrate Conjugates
Subclass:
Glycosyl Compounds
Indication:
Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tach...
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Pharmacodynamics:
Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine may exert its pharmacologic effects by activation of purine (cell surface A<sub>1</sub> and A<su...
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Description:
A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. [PubChem]
Mechanism:
Adenosine slows conduction time through the AV node and can interrupt the reentry pathways through the AV node, resulting in the restoration of normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including P...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
-
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
1.9715 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org