Rx00006 - Albuterol


Name:
Albuterol
Rx ID:
Rx00006
Validation Level:
Reference ID:
DB01001
Primary Indications:
Spinal cord injury
Orphan Indications:
Reversible obstructive airway disease; exercise-induced bronchospasm
Rare Indications:
No annotated rare indications.
Common Indications:
No annotated common indications.
Drug Interactions:
Amitriptyline; Amoxapine; Atenolol; Bisoprolol; Carvedilol; Clomipramine; Desipramine; Doxepin; Esmolol; Imipramine; ...
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Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00006
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
spinal cord injury reversible obstructive airway disease 101 1497 48026 5.668 5.34E-41 1.71e-37

Chemical, Pharmacological and Biological Annotations


ATC Code:
R03CC02 R03AC02;
Brands:
AccuNeb; Aerolin; Asmol; Asthalin; Asthavent; ProAir (Teva); PROAIRHFA; Proventil; Salamol; Ventilan (GlaxoSmithKline); Ventolin (GlaxoSmithKline); Ventoline (GlaxoSmithKline); VENTOLINHFA; Ventorlin (GlaxoSmithKline); VoSpire
Categories:
Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Tocolytic Agents
ChEBI ID:
2549
PubChem ID:
2083
KEGG Drug ID:
D02147
SMILE:
CC(C)(C)NCC(O)C1=CC(CO)=C(O)C=C1
InChI:
1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
Classification:
Kingdom:
Organic Compounds
Superclass:
Benzenoids
Class:
Benzene and Substituted Derivatives
Subclass:
Phenols and Derivatives
Indication:
For symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD.
Pharmacodynamics:
Salbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, leva...
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Description:
Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta recep...
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Mechanism:
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increas...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
-
Caco-2 permeable:
-
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.5275 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org