Rx00007 - Aldesleukin


Name:
Aldesleukin
Rx ID:
Rx00007
Validation Level:
Phenomic Similarity:
0.504
Reference ID:
DB00041
Primary Indications:
Adult metastatic renal cell carcinoma
Orphan Indications:
Primary immunodeficiency disease; T-cell defects; acute myelogenous leukemia; non-Hodgkin's lymphoma
Rare Indications:
Adult metastatic melanoma
Common Indications:
Adult metastatic renal cell carcinoma
Pathways:
SHP2 signaling; IL-7 Signaling Pathway; IL-2 Signaling Pathway; il-2 receptor beta chain in t cell activation; IL2
Drug Interactions:
Clobetasol propionate; Clocortolone; Clozapine; Corticotropin Duloxetine;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00007
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
adult metastatic renal cell carcinoma non-Hodgkin's lymphoma 48 2284 6716 12.626 2.41E-35 7.74e-32

Chemical, Pharmacological and Biological Annotations


ATC Code:
L03AC01
Categories:
Antineoplastic Agents; Anti-HIV Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For treatment of adults with metastatic renal cell carcinoma.
Pharmacodynamics:
Used to treat renal cell carcinoma, Aldesleukin induces the enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human interleukin-2 dependent cell lines, the enhancement of lymphocyte cytotoxicity, the induction of ...
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Description:
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene,...
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Mechanism:
Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta ch...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org