Rx00008 - Alefacept


Name:
Alefacept
Rx ID:
Rx00008
Validation Level:
Reference ID:
DB00092
Primary Indications:
Allogenic solid organ transplantation
Orphan Indications:
Chronic plaque psoriasis
Rare Indications:
No annotated rare indications.
Common Indications:
No annotated common indications.
Drug Interactions:
Canakinumab Rilonacept;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00008
Primary Indication
Secondary Indication

Chemical, Pharmacological and Biological Annotations


ATC Code:
L04AA15
Brand:
Amevive (Biogen Inc.)
Categories:
Dermatologic Agents; Immunosuppressive Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
As an immunosuppressive drug, Alefacept can be used for treatment of moderate to severe chronic plaque psoriasis
Pharmacodynamics:
Interferes with lymphocyte activation by specifically binding to the lymphocyte antigen, CD2, and inhibiting LFA-3/CD2 interaction. Activation of T lymphocytes involving the interaction between LFA-3 on antigen-presenting cells and CD2 on T...
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Description:
Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW...
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Mechanism:
Inhibits T-lymphocyte activation and production by binding to the CD2 lymphocyte antigen.

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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Manhattan, New York City, NY
repurposedb@dudleylab.org