Rx00011 - Alglucerase


Name:
Alglucerase
Rx ID:
Rx00011
Validation Level:
Phenomic Similarity:
0.447
Reference ID:
DB00088
Primary Indications:
Type 1 Gaucher's disease
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Type II Gaucher's disease; type III Gaucher's Disease
Common Indications:
Type I Gaucher disease; moderate anemia; severe anemia; thrombocytopenia; bone disease; significant hepatomegaly; splenomegaly
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00011
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
Type 1 Gaucher's disease type II Gaucher's disease 910 910 910 4433.982 0 0.0

Chemical, Pharmacological and Biological Annotations


ATC Code:
A16AB01
Brand:
Ceredase (Genzyme)
Category:
Enzyme Replacement Agents
KEGG Drug ID:
D09675
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For the treatment of Gaucher's disease (deficiency in glucocerebrosidase)
Pharmacodynamics:
Gaucher disease is characterized by a functional deficiency in Beta-glucocerebrosidase enzymatic activity and the resultant accumulation of lipid glucocerebroside in tissue macrophages which become engorged and are termed Gaucher cells. Gau...
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Description:
Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Bet...
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Mechanism:
Alglucerase catalyzes the hydrolysis of the glycolipid, glucocerebroside, to glucose and ceramide as part of the normal degradation pathway for membrane lipids.

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org