Rx00014 - Alpha1-Proteinase Inhibitor (Human)


Name:
Alpha1-Proteinase Inhibitor (Human)
Rx ID:
Rx00014
Validation Level:
Phenomic Similarity:
0.541
Reference ID:
DB00058
Primary Indications:
Emphysema
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Cystic fibrosis; AAT deficiency-mediated empheysema; congenital alpha1-antitrypsin deficiency; bronchiectasis; chronic obstructive pulmonary disease; bronchopulmonary dysplasia
Common Indications:
Chronic replacement therapy; congenital deficiency of alpha1- proteinase inhibitor; panacinar emphysema
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00014
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
emphysema chronic obstructive pulmonary disease 7233 7233 48026 84.015 0 0.0

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
EMPHYSEMA CHRONIC OBSTRUCTIVE PULMONARY DISEASE 9.12e-34 AGPHD1, ATP6V1D, BICD1, CCL5, CDC6, CHRNA3, CHRNA5, CYP1A1, CYP2A, CYP2A6, CYP2E1, DHX15, EDN1, EPHX1, FUT8, GSTM1, GSTM3, GSTP1, GSTT1, HMOX1, IFNG, IREB2, KIAA0564, LTA, MAN1C1, MAN2B1, MGAT5B, MMP1, MMP12, MMP9, MPO, MYO1D, NAT2, PPT2, SERPINA1, SERPINA3, SERPINE1, SERPINE2, SFTPA2, SFTPB, SFTPC, SNRPF, SOD3, TGFB1, TGFB2, TGFBR3, TLR4, TNF, TNFRSF1A, TNFRSF1B

Chemical, Pharmacological and Biological Annotations


ATC Code:
No ATC code annotated in DrugBank
Brands:
Aralast (Baxter); Prolastin (Talecris Biotherapeutics C formerly Bayer)
Categories:
Serine Proteinase Inhibitors; Trypsin Inhibitors; Enzyme Replacement Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For treatment of panacinar emphysema
Pharmacodynamics:
Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema.
Description:
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Mechanism:
Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 ...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org