Rx00017 - Amantadine


Name:
Amantadine
Rx ID:
Rx00017
Validation Level:
Reference ID:
DB00915
Primary Indications:
Antiviral
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Parkinson's disease
Drug Interactions:
Donepezil; Galantamine; Memantine; Paliperidone; Rivastigmine; Thiothixene; Ziprasidone Zuclopenthixol;
Food Interactions:
Avoid alcohol. Take without regard to meals.

Interactive 3D Model

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Interactive Bipartite Drug Repurposing Graph

Rx00017
Primary Indication
Secondary Indication

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Chemical, Pharmacological and Biological Annotations


ATC Code:
N04BB01
Brands:
Endantadine; PK-Merz; Symadine; Symmetrel (Endo Pharmaceuticals)
Categories:
Antiviral Agents; Dopamine Agents; Antiparkinson Agents; Analgesics, Non-Narcotic
ChEBI ID:
2618
SMILE:
NC12CC3CC(CC(C3)C1)C2
InChI:
1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
Classification:
Kingdom:
Organic Compounds
Superclass:
Organonitrogen Compounds
Class:
Amines
Subclass:
Polyamines
Indication:
For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
Pharmacodynamics:
Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance). It is a derivate of adamantane, like a similar drug rimantadi...
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Description:
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movemen...
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Mechanism:
The mechanism of its antiparkinsonic effect is not fully understood, but it appears to be releasing dopamine from the nerve endings of the brain cells, together with stimulation of norepinephrine response. It also has NMDA receptor antagoni...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.2564 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org