Rx00026 - Apomorphine


Name:
Apomorphine
Rx ID:
Rx00026
Validation Level:
Reference ID:
DB00714
Primary Indications:
Traumatic brain injury; vegetative state
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Hypomobility; Parkinson's disease
Pathways:
Monoamine GPCRs; Amine ligand-binding receptors; GPCRs, Class A Rhodopsin-like; Nicotine Activity on Dopaminergic Neurons; Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics; Hypothetical Networ ...Click to show more
Drug Interactions:
Artemether; Entacapone; Lumefantrine; Paliperidone; Tacrolimus; Thiothixene; Toremifene; Voriconazole; Vorinostat; Ziprasidone; ...
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Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00026
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
traumatic brain injury hypomobility 13 7675 473 14.449 2.11E-11 6.77e-08

Chemical, Pharmacological and Biological Annotations


ATC Code:
No ATC code annotated in DrugBank
Brands:
Ixense (Takeda (discontinued)); Spontane; Uprima (Abbott (discontinued))
Categories:
Antiparkinson Agents; Dopamine Agonists; Antidyskinetics
ChEBI ID:
48538
PubChem ID:
6005
KEGG Drug ID:
D07460
SMILE:
[H][C@]12CC3=C(C(O)=C(O)C=C3)C3=CC=CC(CCN1C)=C23
InChI:
1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Alkaloids and Derivatives
Class:
Aporphines
Subclass:
Indication:
For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Pharmacodynamics:
Apomorphine is a type of dopaminergic agonist, a morphine derivative which primarily affects the hypothalamic region of the brain. Drugs containing this substance are sometimes used in the treatment of Parkinson's disease or erectile dysfun...
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Description:
A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its us...
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Mechanism:
The precise mechanism of action of apomorphine as a treatment for Parkinson's disease is unknown, although it is believed to be due to stimulation of post-synaptic dopamine D2-type receptors within the brain. Apomorphine has been shown to i...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.6446 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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Manhattan, New York City, NY
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