Rx00028 - Aripiprazole


Name:
Aripiprazole
Rx ID:
Rx00028
Validation Level:
Phenomic Similarity:
0.617
Reference ID:
DB01238
Primary Indications:
Tourette syndrome
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Schizophrenia; bipolar I disorder; major depressive disorder; autistic disorder
Pathways:
Monoamine GPCRs; Amine ligand-binding receptors; Nalbuphine Action Pathway; Heroin Action Pathway; Levomethadyl Acetate Action Action Pathway; Levallorphan Action Pathway; Dimethylthiambutene Action P ...Click to show more
Drug Interactions:
Carbamazepine; Dihydroquinidine barbiturate; Etravirine; Itraconazole; Ketoconazole; Quinidine; Quinidine barbiturate; Tacrine; Telithromycin; Terbinafine; ...
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Food Interactions:
Avoid alcohol (possible additive effect to CNS). Food has no significant effect on absorption. Take without regard to meals.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00028
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
Tourette syndrome bipolar I disorder 52 477 34537 12.736 1.47E-37 4.7e-34

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
TOURETTE SYNDROME SCHIZOPHRENIA 1.48e-12 ADRA2A, APP, AUTS2, BDNF, BTBD9, CDH2, CNR1, CNTNAP2, COL8A1, COMT, DBH, DLGAP3, DRD1, DRD2, DRD3, DRD4, GDNF, GSTP1, HCRTR2, HDC, HLA-DRB1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, IL10, IL10RA, IL12B, IL1A, IL1B, IL1RN, IMMP2L, MAOA, MAPT, MOG, NRXN1, OFCC1, OLIG2, PSEN1, PSEN2, RBFOX1, SGCE, SLC1A3, SLC6A2, SLC6A3, SLC6A4, TDO2, TNF, XRCC1

Chemical, Pharmacological and Biological Annotations


ATC Code:
N05AX12
Brand:
Abilitat
Category:
Antipsychotic Agents
ChEBI ID:
31236
PubChem ID:
60795
KEGG Drug ID:
D01164
SMILE:
ClC1=CC=CC(N2CCN(CCCCOC3=CC4=C(CCC(=O)N4)C=C3)CC2)=C1Cl
InChI:
1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Classification:
Kingdom:
Organic Compounds
Superclass:
Heterocyclic Compounds
Class:
Piperazines
Subclass:
Phenylpiperazines
Indication:
For the treatment of schizophrenia and related psychotic disorders.
Pharmacodynamics:
Aripiprazole is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Aripiprazole is a selective monoaminergic antagonist with high affinity for the serotonin...
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Description:
Aripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appe...
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Mechanism:
Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism a...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Inhibitor
CYP450 2D6 substrate:
Inhibitor
CYP450 2C19 substrate:
Inhibitor
CYP450 inhibitory promiscuity:
High CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.8894 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Inhibitor

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org