Rx00038 - Beclomethasone Dipropionate


Name:
Beclomethasone Dipropionate
Rx ID:
Rx00038
Validation Level:
Phenomic Similarity:
0.55
Reference ID:
DB00394
Primary Indications:
Graft-versus-host disease; intestinal graft-versus-host disease; gastrointestinal graft-versus-host disease; Crohn's disease; ulcerative colitis
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Perennial rhinitis; allergic rhinitis; nasal polyps; asthma
Pathways:
Serotonin Receptor 4-6-7 and NR3C Signaling; Regulation of Androgen receptor activity
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No food effects were found when given with beclomethasone dipropionate.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00038
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
ulcerative colitis asthma 923 9520 107112 3.652 6.00E-220 1.93e-216
Crohn's disease asthma 1038 11834 107112 3.304 1.15E-216 3.7e-213
intestinal graft-versus-host disease asthma 53 384 107112 5.199 3.02E-20 9.71e-17
graft-versus-host disease asthma 53 384 107112 5.199 3.02E-20 9.71e-17
gastrointestinal graft-versus-host disease asthma 53 384 107112 5.199 3.02E-20 9.71e-17

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
ULCERATIVE COLITIS ASTHMA 1.97e-60 ABCB1, ABP1, ACE, ADAD1, ADRA2A, AGER, ATG16L1, BTNL2, C11orf30, C5orf56, CAT, CCL11, CCL2, CCL24, CCL26, CCL3, CCL5, CCND1, CCR5, CCR6, CD14, CD209, CD40, CDH1, CDKAL1, CHRNA3, CIITA, CREM, CTLA4, CXCL12, CXCL9, CXCR1, CXCR2, CYBA, CYP2D6, CYP3A4, CYP3A5, DEFB1, F13A1, F2, F5, FAS, FCGR2A, FCGR3A, FCGR3B, FKBP5, FOS, FUT2, GCKR, GSDMB, GSTM1, GSTP1, GSTT1, HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-G, HMOX1, HNMT, HP, IBD5, ICAM1, ICOSLG, IFNG, IL10, IL10RA, IL10RB, IL11, IL12B, IL13, IL17A, IL17F, IL18, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RL1, IL1RN, IL2, IL20, IL21, IL22, IL23R, IL26, IL27, IL2RA, IL2RB, IL33, IL4, IL4R, IL5, IL6, IL7R, IL8, IRAK3, IRF5, IRGM, ITLN1, JAK2, KRAS, LRRK2, LTA, LYRM4, MAGI2, MAP3K1, MBL2, MEFV, MICA, MICB, MIF, MIR146A, MMP1, MMP12, MMP2, MMP3, MMP7, MMP8, MMP9, MST1, MTHFR, MUC19, MYD88, NAT1, NAT2, NCF4, NFE2L2, NFKB1, NFKBIL1, NKX2-3, NLRP3, NOD1, NOD2, NOS1, NOS2, NOS3, NOTCH4, NOX3, NPSR1, NQO1, NR1I2, NR3C1, ORMDL3, PADI4, PBX2, PDCD1, PLA2G7, PLCL1, PPARG, PTGER4, PTGIR, PTGS1, PTGS2, PTPN2, PTPN22, PUS10, REL, RNASE3, RTEL1, RUNX1, RUNX3, SELS, SERPINA1, SFTPD, SLC11A1, SLC22A23, SLC22A4, SLC22A5, SLC39A11, SOD2, SPP1, STAT3, STAT4, STAT6, TF, TGFB1, TIMP1, TLR1, TLR2, TLR4, TLR6, TLR9, TNF, TNFRSF14, TNFRSF17, TNFRSF1A, TNFRSF1B, TNFRSF6B, TNFSF10, TNFSF15, TP53, TRAF6, UGT1A7, VDR, VTCN1, XRCC1, ZNF365, ZPBP2
GRAFT-VERSUS-HOST DISEASE ASTHMA 4.45e-31 ABCB1, ABCC1, ABCC2, ABO, BCL2A1, CCL2, CCL5, CCR5, CCR6, CD14, CD28, CD86, CTLA4, CYP2C19, CYP3A5, DARC, EDN1, ESR1, FAS, FCGR2A, FCGR3A, FCRL3, GSTA1, GSTM1, GSTP1, GSTT1, GZMB, HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-E, HLA-G, HMGB1, ICAM1, ICOS, IFNA1, IFNG, IFNGR1, IFNGR2, IL10, IL10RA, IL10RB, IL15RA, IL17A, IL17F, IL18, IL1A, IL1B, IL1R1, IL1RN, IL2, IL23R, IL4, IL4R, IL6, IL6R, IL7R, IRF1, IRF3, KIR2DL4, LTA, MBL2, MPO, MTHFR, NFKBIA, NOD2, NOS1, NOS2, PADI4, PARP1, PECAM1, PTPN22, SELL, SMAD3, TGFB1, TGFB2, TGFBR2, TLR1, TLR10, TLR2, TLR3, TLR4, TLR5, TLR6, TLR8, TLR9, TNF, TNFRSF1A, TNFRSF1B, TNFSF13B, VDR, VEGFA, XRCC1

Chemical, Pharmacological and Biological Annotations


ATC Code:
A07EA07; D07AC15; R01AD01 R03BA01;
Brands:
Aerobec (Teva); Aldecin (Schering-Plough); Anceron; Andion; Beclacin (Mayado Seiyaku); Becloforte (GlaxoSmithKline); Beclomet (Orion); Beclorhinol (Chiesi); Becloval; Beclovent (GlaxoSmithKline); Becodisks (GlaxoSmithKline); Beconase (GlaxoSmithKline); Beconasol; Becotide (GlaxoSmithKline); Clenil-A; Entyderma; Inalone (GlaxoSmithKline); Korbutone; orBec (DOR BioPharma, Inc.); Rino-Clenil (Chiesi); Rivanase; Sanasthmax (Chiesi); Sanasthmyl; Vancenase; Vanceril
Categories:
Anti-Arrhythmia Agents; Corticosteroids
ChEBI ID:
3001
KEGG Drug ID:
D07495
SMILE:
[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
InChI:
1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Lipids
Class:
Steroids and Steroid Derivatives
Subclass:
Gluco/mineralocorticoids, Progestogins and Derivatives
Indication:
Used in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older, and in treating symptoms for allergic rhinitis (seasonal or perennial) in patients 12 years of age and older. Also being investigated ...
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Pharmacodynamics:
Beclometasone, a synthetic halogenated glucocorticoid with antiinflammatory and vasoconstrictive effects, is used for treating steroid-dependent asthma, allergic or nonallergic rhinitis, or recurrent nasal polyps.
Description:
Beclomethasone dipropionate is a prodrug of the free form, Beclomethasone (beclomethasone-17-monopropionate). An anti-inflammatory, synthetic corticosteroid, it is used topically as an anti-inflammatory agent and in aerosol form for the tre...
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Mechanism:
Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of i...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.1115 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org