Rx00045 - Bleomycin


Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00045
Primary Indication
Secondary Indication

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
lymphomas non-Hodgkin's lymphoma 4708 4708 6716 600.793 0 0.0
recurrent pleural effusions malignant pleural effusion 733 733 733 5504.671 0 0.0
embryonal cell Testicular Carcinoma teratocarcinoma 458 458 6096 661.897 0 0.0
Hodgkin's disease Hodgkin's lymphoma 1346 1346 1346 2997.715 0 0.0
non-Hodgkin's lymphoma Hodgkin's lymphoma 1346 6716 1346 600.793 0 0.0
Squamous cell carcinoma of neck Squamous cell carcinoma of head 312 312 312 12932.449 0 0.0
teratocarcinoma embryonal cell Testicular Carcinoma 458 6096 458 661.897 0 0.0
Squamous cell carcinoma of head Squamous cell carcinoma of neck 312 312 312 12932.449 0 0.0
malignant pleural effusion teratocarcinoma 82 733 6096 74.046 4.05E-118 1.3e-114

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
LYMPHOMAS NON-HODGKIN'S LYMPHOMA 9.64e-259 1231, ABCB1, ABCG2, ACAA1, ACBD3, ADAM17, ADAM19, ADH5, ADIPOQ, ADRB2, ADRB3, AHR, AICDA, AIF1, AKR1A1, AKR1C1, AKR1C3, ALDH1L1, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, ALOX5AP, ALOXE3, APEX1, APOA2, APOA4, APOB, APOE, AR, ATG9B, ATM, B3GNT3, BACH2, BAD, BAG1, BAG3, BAG4, BAG5, BAK1, BAX, BCL10, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L12, BCL2L13, BCL2L14, BCL2L2, BCL6, BCL7A, BCL7C, BCLAF1, BHMT, BID, BIK, BIRC3, BLM, BMF, BNIP2, BNIP3, BRAF, BRCA1, BRCA2, C14orf101, C1QA, C1QB, C1QC, C1QTNF7, C1RL, C1S, C2, C3, C3AR1, C4A, C4BPA, C4BPB, C5, C5AR1, C6, C6orf15, C7, C8B, C9, CARD11, CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP8AP2, CASP9, CAT, CBS, CCL1, CCL11, CCL13, CCL18, CCL2, CCL20, CCL24, CCL26, CCL5, CCL7, CCL8, CCND1, CCND3, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD14, CD180, CD209, CD28, CD38, CD40, CD46, CD5, CD55, CD59, CD7, CD79A, CD79B, CD93, CDC42BPB, CDC6, CDH1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CEBPA, CETP, CFB, CFD, CFH, CFHR1, CFHR5, CFLAR, CHMP7, CHUK, CLCA1, CLCA2, CLDN9, CLU, COMT, CR1, CR2, CREB1, CRY2, CSF3, CTLA4, CTNNB1, CX3CR1, CXCL12, CXCL13, CXCR1, CXCR2, CXCR4, CXCR5, CYBA, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP21A2, CYP24A1, CYP27B1, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, DCK, DEFA6, DEFB1, DEFB126, DFFB, DHFR, DICER1, DLG5, DNMT3A, DRD2, DRD3, DRD5, DROSHA, DUSP2, EDN1, EPHX1, EPHX2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ESR1, ESR2, ETS1, ETV6, EXOC2, EZH2, FAM179B, FBXW7, FCER1A, FCER1G, FCER2, FCGR2A, FCGR2B, FCGR3A, FCGR3B, FCGRT, FDFT1, FGF2, FGFR4, FGG, FLT1, FN1, FOXO1, FPGS, G6PD, GGH, GH1, GHR, GHRL, GOLGA7, GPC1, GPR44, GPX1, GPX2, GPX3, GPX4, GSTM1, GSTM3, GSTP1, GSTT1, H2AFX, HAVCR2, HDAC7, HES7, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HMGCS1, HMGCS2, HP, HRAS, HRK, HSD17B1, HSD17B2, HSD3B1, HSD3B2, ICAM1, ICAM2, ICAM3, ICAM4, ICAM5, ICOS, IDH1, IDH2, IFNA1, IFNG, IFNGR1, IFNGR2, IGF1, IGF1R, IGF2, IGF2R, IGFBP1, IGFBP3, IGHV@, IKBKB, IL10, IL10RA, IL12A, IL12B, IL13, IL15, IL15RA, IL16, IL18, IL18RAP, IL1A, IL1B, IL1R1, IL1R2, IL1RN, IL2, IL21, IL3, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7R, IL8, IL9, IL9R, INSL3, IRF4, IRF8, ITGB2, ITGB3, JAK2, JAK3, KDR, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, KRAS, KRT81, LEP, LEPR, LIG1, LIG3, LIG4, LIPC, LMO2, LNX2, LPL, LPXN, LSP1, LTA, LTBR, LY6G6F, MALT1, MAP3K5, MASP2, MBD2, MBL2, MBP, MC1R, MDM2, MGMT, MIF, MIR155, MIR202, MIR499, MITF, MLH1, MMP1, MMP2, MMP3, MMP9, MPO, MRE11A, MS4A1, MSH2, MSH3, MSH5, MSMB, MTHFD1, MTHFD2, MTHFR, MTHFS, MTR, MTRR, MYC, MYD88, NAT1, NAT2, NBN, NCF2, NCF4, NCOA1, NCOA3, NFKB1, NFKBIA, NFKBIB, NOD2, NOS1, NOS2, NOS3, NOTCH1, NOTCH2, NPAS2, NPC1, NPC2, NPY, NQO1, NR1H2, NR1H3, NR3C1, NRAS, OCA2, OGG1, PARD3, PARG, PARP1, PDSS1, PGR, PIM1, POMC, PON1, PPARG, PRF1, PRKAA2, PRKAG3, PRKDC, PRL, PRLR, PRRC2A, PSMB1, PTGDR, PTGES, PTGS1, PTGS2, PTP4A1, PTPN1, PVT1, RAC1, RAC2, RAD23B, RAD50, RAD51, RAD54L, RAET1L, RAG1, RAG2, RB1, REL, RFC1, RIPK1, RIPK2, RIPK3, RXRA, RYR3, SECTM1, SELE, SELP, SELPLG, SERPINA6, SERPING1, SETD8, SH2D1A, SHBG, SHMT1, SHMT2, SIRT1, SLC19A1, SLC23A1, SLC23A2, SLC3A2, SLC6A3, SLC7A5, SLC7A8, SLCO1B1, SLCO1B3, SOCS1, SOCS2, SOCS3, SOCS4, SOD1, SOD2, SOD3, SRD5A1, STAR, STARD3NL, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, SUN2, TAF1, TAP2, TCN1, TERT, TET2, TGFB1, TICAM1, TIMP1, TIMP2, TIMP3, TLR1, TLR10, TLR2, TLR4, TLR6, TLR9, TNF, TNFAIP3, TNFAIP8, TNFRSF10A, TNFRSF14, TNFRSF17, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF13B, TNFSF8, TOP2A, TP53, TP53I3, TRADD, TRAF1, TRAF2, TRAF5, TRAF6, TRAM1, TSLP, TSPO2, TYMS, TYR, UGT1A1, UNC13D, VCAM1, VDR, VEGFA, WRN, XPA, XPC, XRCC1, XRCC2, XRCC3, XRCC4, ZFP91
HODGKIN'S DISEASE HODGKIN'S LYMPHOMA 3.68e-220 ABCB1, AICDA, APEX1, ATM, BAX, BCL10, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L2, BCL6, BCL7A, BCL7C, BLM, BLMH, BMF, BRCA1, BRCA2, CASP1, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP8AP2, CASP9, CAST, CCL17, CCND1, CCNH, CD14, CD28, CD4, CD40, CD5, CD70, CD79A, CD79B, CD81, CFLAR, CHEK2, CHUK, CXCL12, CXCR1, CXCR2, CYP1A1, CYP2C9, CYP2D6, CYP2E1, CYP3A4, EOMES, EPHX1, ERAP1, ERCC1, ERCC2, ERCC3, ERCC5, ERCC6, FADD, FAS, FASLG, FCGR2A, FGFR2, FLJ45983, GATA3, GPX1, GPX2, GPX3, GPX4, GSTA1, GSTM1, GSTP1, GSTT1, HBS1L, HCG9, HFE, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HPSE, ICAM1, IFNG, IKBKB, IL10, IL10RA, IL10RB, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL15, IL18, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RN, IL2, IL4, IL4R, IL5, IL6, IL6R, IL6ST, IL8, IL9, IRF4, ITGA6, JAK3, KRT81, LIG1, LIG3, LIG4, LMO2, LMTK2, LTA, LTC4S, MDM2, MGMT, MICB, MLH1, MRE11A, MS4A2, MTHFR, MTR, MYB, MYC, MYD88, NBN, NFKB1, NFKB2, NFKBIA, NFKBIE, NFRKB, NQO1, OGG1, PARP1, PIM1, PKNOX2, POLB, PPARG, PRKDC, PTGS2, PTPN1, PVT1, RAD50, RAD51, RAD54L, RAG1, RAG2, REL, RELA, RELB, RIPK1, RIPK2, RPL13P2, SHMT1, SOCS1, STAT1, STAT3, STAT5A, STAT6, TANK, TARBP2, TERT, TFRC, TGFB1, TLR1, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR8, TLR9, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF18, TNFRSF9, TNFSF10, TNFSF13, TNFSF14, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TP53, TP53I3, TRADD, TRAF2, TRAF5, TRAF6, TYMS, UGT1A1, UGT1A6, VCAM1, VEGFA, WRN, XPC, XPO5, XRCC1, XRCC2, XRCC3, XRCC4
NON-HODGKIN'S LYMPHOMA HODGKIN'S LYMPHOMA 5.39e-100 ABCB1, AICDA, APEX1, ATM, BAX, BCL10, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L2, BCL6, BCL7A, BCL7C, BLM, BMF, BRCA1, BRCA2, CASP1, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP8AP2, CASP9, CCND1, CD14, CD28, CD40, CD5, CD79A, CD79B, CFLAR, CHUK, CXCL12, CXCR1, CXCR2, CYP1A1, CYP2C9, CYP2D6, CYP2E1, CYP3A4, EPHX1, ERCC1, ERCC2, ERCC3, ERCC5, ERCC6, FCGR2A, GPX1, GPX2, GPX3, GPX4, GSTM1, GSTP1, GSTT1, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, ICAM1, IFNG, IKBKB, IL10, IL10RA, IL12A, IL12B, IL13, IL15, IL18, IL1A, IL1B, IL1R1, IL1R2, IL1RN, IL2, IL4, IL4R, IL5, IL6, IL6R, IL8, IL9, IRF4, JAK3, KRT81, LIG1, LIG3, LIG4, LMO2, LTA, MDM2, MGMT, MLH1, MRE11A, MTHFR, MTR, MYC, MYD88, NBN, NFKB1, NFKBIA, NQO1, OGG1, PARP1, PIM1, PPARG, PRKDC, PTGS2, PTPN1, PVT1, RAD50, RAD51, RAD54L, RAG1, RAG2, REL, RIPK1, RIPK2, SHMT1, SOCS1, STAT1, STAT3, STAT5A, STAT6, TERT, TGFB1, TLR1, TLR10, TLR2, TLR4, TLR6, TLR9, TNF, TNFRSF10A, TNFRSF14, TNFSF8, TP53, TP53I3, TRADD, TRAF2, TRAF5, TRAF6, TYMS, UGT1A1, VCAM1, VEGFA, WRN, XPC, XRCC1, XRCC2, XRCC3, XRCC4

Chemical, Pharmacological and Biological Annotations


ATC Code:
L01DC01
Brands:
Blenoxane; Bleo
Category:
Antibiotics, Antineoplastic
ChEBI ID:
22907
PubChem ID:
5360373
SMILE:
C[C@@H](O)[C@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@@H](NC(=O)C1=C(C)C(N)=NC(=N1)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](OC1OC(CO)C(O)C(O)C1OC1OC(CO)C(O)C(OC(N)=O)C1O)C1=CN=CN1)C(=O)NCCC1=NC(=CS1)C1=NC(=CS1)C(=O)NCCC[S+](C)C
InChI:
1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29?,30?,34-,35-,36-,37?,38?,39?,40?,41-,42?,43?,53?,54?/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids and Derivatives
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Pharmacodynamics:
Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-...
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Description:
A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 an