Rx00047 - Botulinum Toxin Type A


Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00047
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

Click row to show all

Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
severe primary axillary hyperhidrosis adult severe axillary hyperhidrosis 5451 5451 5451 740.217 0 0.0
abnormal neck pain adult severe axillary hyperhidrosis 660 25704 5451 19.007 0 0.0
moderate glabellar lines adult severe glabellar lines 1798 1798 1798 2244.118 0 0.0
adult cervical dystonia adult dystonia 702 702 9445 427.202 0 0.0
excessive underarm sweating adult severe axillary hyperhidrosis 5451 5451 5451 740.217 0 0.0
blepharospasm adult blepharospasm 498 498 498 8102.257 0 0.0
dystonia adult cervical dystonia 702 9445 702 427.202 0 0.0
benign essential blepharospasm adult blepharospasm 498 498 498 8102.257 0 0.0
severe glabellar lines adult severe glabellar lines 1798 1798 1798 2244.118 0 0.0
strabismus adult limb spasticity 185 5512 7598 17.824 9.02E-156 2.9e-152
severe frown lines adult limb spasticity 90 3454 7598 13.837 7.28E-68 2.34e-64
moderate frown lines adult limb spasticity 90 3454 7598 13.837 7.28E-68 2.34e-64
abnormal head position adult limb spasticity 29 619 7598 24.88 6.23E-30 2e-26

Chemical, Pharmacological and Biological Annotations


ATC Code:
M03AX01
Categories:
Neuromuscular Blocking Agents; Anti-Wrinkle Agents; Antidystonic Agents
KEGG Drug ID:
D00783
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For the treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia. Also for the treatment of severe primary axillary hyperhidrosis that is inadequately manage...
Click to show more...
Pharmacodynamics:
A 150 kDa neurotoxic protein produced from fermentation of Hall strain Clostridium botulinum type A grown in a medium containing casein hydrolysate, glucose and yeast extract. It is purified from the culture solution by dialysis and a serie...
Click to show more...
Description:
Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation.
Mechanism:
Botulinum Toxin Type A blocks neuromuscular transmission by binding to acceptor sites on motor or sympathetic nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. This inhibition occurs as the neurotox...
Click to show more...

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org