Rx00056 - Capsaicin


Name:
Capsaicin
Rx ID:
Rx00056
Validation Level:
Phenomic Similarity:
0.473
Reference ID:
ChEMBL294199
Primary Indications:
Pain; arthritis; backache; strains; sprains; peropheral neuropathy; post-hepatic neuralgia; shingles; psoriasis
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Erythromelalgia; HIV-associated neuropathy; intermetatarsal neuroma; Morton's Neuroma
Common Indications:
Neuropathic pain; postherpetic neuralgia
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00056
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
backache persistent pain 4551 41016 11357 39.421 0 0.0
pain persistent pain 11357 35768 11357 112.808 0 0.0
post-hepatic neuralgia postherpetic neuralgia 5070 5070 5070 795.843 0 0.0
arthritis persistent pain 1762 24549 11357 25.5 0 0.0
shingles HIV-associated neuropathy 854 6989 11821 41.708 0 0.0
psoriasis persistent pain 236 9320 11357 8.996 1.83E-134 5.88e-131
sprains persistent pain 140 3142 11357 15.83 1.24E-111 4e-108
peropheral neuropathy postherpetic neuralgia 45 701 5070 51.088 5.71E-59 1.83e-55

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
BACKACHE NEUROPATHIC PAIN 1.8e-40 ABCB1, ADRA1A, ADRA2A, ADRA2C, BDNF, CHRM1, CNR1, COL9A2, COMT, CYP2D6, DRD2, ESR1, GABRA2, GABRB1, GCH1, GLRA1, HLA-B, HLA-DRB1, HTR1A, HTR2A, IL1A, IL1B, IL1RN, MMP1, NOS3, OPRM1, TAC1, TNF
PAIN NEUROPATHIC PAIN 1.96e-27 ABCB1, ADRA1A, ADRA2A, ADRA2C, BDNF, CHRM1, CNR1, COL9A2, COMT, CYP2C19, CYP2D6, DRD2, ESR1, GABRA2, GABRB1, GCH1, GLRA1, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, HTR1A, HTR2A, HTR2C, IFNG, IL10, IL1A, IL1B, IL1RN, IL2, IL4, IL4R, IL6, MMP1, NOS3, OPRM1, SLC6A4, TAC1, TNF, TRPA1, TRPM8, TRPV1
PSORIASIS NEUROPATHIC PAIN 1.95e-10 ABCB1, BDNF, CYP2C19, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, HTR2A, IFNG, IL10, IL1A, IL1B, IL1RN, IL2, IL4, IL4R, IL6, NOS3, SLC6A4, TNF
ARTHRITIS NEUROPATHIC PAIN 7.96e-08 ABCB1, ADRA1A, CNR1, COL9A2, COMT, CYP2C19, CYP2D6, ESR1, GCH1, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, HTR1A, HTR2A, IFNG, IL10, IL1A, IL1B, IL1RN, IL2, IL4, IL4R, IL6, MMP1, NOS3, SLC6A4, TNF, TRPV1
SHINGLES NEUROPATHIC PAIN 2.17e-06 HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, IL10

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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