Rx00060 - Chlorhexidine


Name:
Chlorhexidine
Rx ID:
Rx00060
Validation Level:
Reference ID:
DB00878
Primary Indications:
Oral mucositis; bone marrow transplantation
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Gingivitis
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00060
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
oral mucositis gingivitis 47 1505 4155 30.327 1.92E-51 6.16e-48

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
ORAL MUCOSITIS GINGIVITIS 1.45e-14 BRAF, IFNG, IL10, IL18, IL1A, IL1B, IL1RN, IL6, MMP9, PTGER3, TLR4, TNF

Chemical, Pharmacological and Biological Annotations


ATC Code:
A01AB03; B05CA02; D08AC02; D09AA12; R02AA05; S01AX09; S02AA09; S03AA04 D08AE02;
Brands:
Cida-Stat (Ecolab); Corsodyl (GlaxoSmithKline); Dyna-Hex (Xttrium); Exidine (Xttrium); Hexadol (Green Cross); Hibidil (CPS Cito Pharma); Hibiscrub (AstraZeneca); Hibispray; Hibitane (Imperial Chemical Industries); Microderm (Johnson & Johnson); Oro-Clense (Germiphene); Periogard Oral Rinse (Colgate); Pharmaseal Scrub Care (CareFusion); Prevacare R (Johnson & Johnson); Rotersept (Roter); Sterilon (Emcure); Tubulicid
Categories:
Anti-Infective Agents; Anti-Infective Agents, Local; Disinfectants; Mouthwashes
ChEBI ID:
3614
KEGG Drug ID:
D07668
SMILE:
ClC1=CC=C(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC2=CC=C(Cl)C=C2)C=C1
InChI:
1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)
Classification:
Kingdom:
Organic Compounds
Superclass:
Benzenoids
Class:
Benzene and Substituted Derivatives
Subclass:
Halobenzenes
Indication:
For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in h...
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Pharmacodynamics:
Chlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action m...
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Description:
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. [PubChem]
Mechanism:
Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of th...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
High CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
1.7711 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org