Rx00069 - Coagulation Factor Viia (Recombinant)


Name:
Coagulation Factor Viia (Recombinant)
Rx ID:
Rx00069
Validation Level:
Phenomic Similarity:
0.71
Reference ID:
DB00036
Primary Indications:
Hemorrhagic complications; hemophilia A; hemophilia B
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Glanzmann's thrombasthenia; bleeding; intracranial hemorrhage; diffuse alveolar hemorrhage
Common Indications:
Bleeding episodes; Factor VII Deficiency; acquired hemophilia
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00069
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

Click row to show all

Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
hemophilia A bleeding 57 749 2111 145.459 1.94E-99 6.23e-96
hemophilia B bleeding 15 132 2111 217.202 7.00E-30 2.25e-26

Chemical, Pharmacological and Biological Annotations


ATC Code:
No ATC code annotated in DrugBank
Brand:
NovoSeven (Novo Nordisk)
Categories:
Coagulants; Thrombotic Agents
KEGG Drug ID:
D00172
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For treatment of hemorrhagic complications in hemophilia A and B
Pharmacodynamics:
Used in the treatment of bleeding episodes in hemophilia A or B. NovoSeven is recombinant Factor VIIa and, when complexed with tissue factor can activate coagulation Factor X to Factor Xa, as well as coagulation Factor IX to Factor IXa. Fac...
Click to show more...
Description:
Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cl...
Click to show more...
Mechanism:
NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin.

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org