Rx00071 - Collagenase


Name:
Collagenase
Rx ID:
Rx00071
Validation Level:
Phenomic Similarity:
0.667
Reference ID:
DB00048
Primary Indications:
Debridement of necrotic tissue; severe burns; dermal ulcers; decubitus ulcers
Orphan Indications:
Peyronie's disease
Rare Indications:
Adult Dupuytren's contracture with a palpable cord
Common Indications:
Chronic dermal ulcer; severe burn
Drug Interactions:
Eptifibatide;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00071
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
dermal ulcers chronic dermal ulcer 1349 1349 15841 254.714 0 0.0
decubitus ulcers chronic dermal ulcer 6844 6844 15841 254.714 0 0.0
severe burn chronic dermal ulcer 248 4175 15841 15.13 7.77E-191 2.5e-187

Chemical, Pharmacological and Biological Annotations


ATC Code:
D03BA02
Brands:
Cordase; Santyl (Advance Biofactures Corp)
Categories:
No categories annotated in DrugBank
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
Used to promote debridement of necrotic tissue in the treatment of severe burns and dermal ulcers including decubitus ulcers.
Pharmacodynamics:
Used in the treatment of skin ulcers and sever burns, collagenase is able to digest collagen in necrotic tissue at physiological pH by hydrolyzing the peptide bonds of undenatured and denatured collagen. Collagenase thus contributes towards...
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Description:
The enzyme collagenase is derived from fermentation of Clostridium histolyticum
Mechanism:
Collagenase is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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Manhattan, New York City, NY
repurposedb@dudleylab.org