Rx00072 - Corticotropin


Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00072
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
juvenile spasms infantile spasms 83 83 83 48613.542 0 0.0
optic neuritis multiple sclerosis 338 848 5796 277.478 0 0.0
diffuse posterior uveitis multiple sclerosis 40 2723 5796 10.226 1.92E-26 6.16e-23
sarcoidosis multiple sclerosis 53 5425 5796 6.801 2.98E-26 9.55e-23
systemic lupus erythematosus multiple sclerosis 39 3955 5796 6.865 6.58E-20 2.11e-16
iridocyclitis multiple sclerosis 25 1295 5796 13.439 7.71E-20 2.47e-16
iritis multiple sclerosis 25 1295 5796 13.439 7.71E-20 2.47e-16
rheumatoid arthritis multiple sclerosis 48 7378 5796 4.529 5.20E-17 1.67e-13

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
SYSTEMIC LUPUS ERYTHEMATOSUS MULTIPLE SCLEROSIS 7.5e-71 1231, 6775066, 934, ABCA7, ABCB1, ACE, AFF3, AGER, AGT, ANO3, APOE, ATG5, BAG6, BANK1, BCL2, BDNF, BLK, BRD2, BTNL2, C5, C6orf10, C6orf26, C6orf27, C6orf47, C7, CACNA1A, CARD11, CASP8, CBS, CCHCR1, CCL14, CCL2, CCL5, CCL8, CCR2, CCR5, CCR6, CD226, CD24, CD274, CD28, CD4, CD40, CD40LG, CD46, CD80, CD86, CDSN, CFB, CFH, CFHR1, CFHR3, CIITA, CLEC16A, COMT, CR1, CSMD1, CTLA4, CXCL10, CXCL12, CXCR5, DEFB1, EHMT2, ERBB3, ERCC2, ESR1, F2, FAM167A, FAS, FASLG, FCGR2A, FCGR2B, FCGR3A, FCGR3B, FCRL3, FEN1, FOXP3, GABBR1, GATA3, GIMAP5, GLDC, GSTM1, GSTP1, GSTT1, GTF2H4, HAVCR1, HCG9, HFE, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-F, HLA-F-AS1, HLA-G, HMHA1, HMOX1, HSPA1A, HSPA1B, HSPA1L, IBD5, ICAM1, ICOS, IER3, IFI16, IFIH1, IFNA17, IFNG, IFNGR1, IFNGR2, IKZF1, IL10, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL16, IL17A, IL17F, IL18, IL19, IL1A, IL1B, IL1R1, IL1RN, IL2, IL20, IL21, IL21R, IL22, IL23A, IL23R, IL24, IL28RA, IL2RA, IL4, IL4R, IL5, IL6, IL7R, IL8, IRF4, IRF5, IRF8, ITGAM, ITGAX, JAK2, JUN, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1, L1CAM, LAMC2, LCE3B, LCE3C, LIG4, LOC100506023, LST1, LTA, MAN2A1, MAVS, MEFV, MERTK, MICA, MICB, MIF, MIR146A, MMP2, MMP3, MMP9, MOG, MPO, MSH5, MTHFR, MTRR, MYO9B, NAT1, NAT2, NBN, NDUFS4, NFKB1, NFKBIA, NFKBIL1, NLRP1, NLRP3, NOD2, NOS1, NOS2, NOS3, NOTCH4, NR3C1, NRM, OLIG3, OPN1LW, OR12D3, OR2H1, OR2H2, OSMR, P2RX7, PADI2, PADI4, PARK2, PARP1, PBMUCL1, PDCD1, PON1, POU5F1, PPARG, PPT2, PRDM1, PRL, PRLR, PRRC2A, PSMB8, PSMB9, PTEN, PTGER4, PTGS2, PTPN22, PTPRC, PTPRM, PXK, RAD52, RBFOX1, RDBP, REL, RNF39, RUNX1, SELE, SELP, SERPINB2, SERPINE1, SH2B3, SH2D1A, SLC11A1, SLC15A4, SLC19A1, SLC22A4, SLC44A4, SOCS1, SPP1, ST8SIA2, STAT1, STAT3, STAT4, TAP1, TAP2, TGFB1, TGFB2, TGFBR2, TGFBR3, TLR2, TLR3, TLR4, TLR5, TLR7, TLR8, TLR9, TMEM39A, TNF, TNFAIP3, TNFRSF13B, TNFRSF1A, TNFRSF1B, TNFRSF6B, TNFSF10, TNPO3, TNXB, TP53, TPH2, TRAF1, TRB@, TRIM10, TRIM15, TRIM26, TRIM31, TRIM40, TYK2, UBD, UCP2, VARS2, VDR, VEGFA, XKR6, XRCC1, XRCC3, XRCC4
RHEUMATOID ARTHRITIS MULTIPLE SCLEROSIS 1.42e-68 1231, 6775066, 934, A2M, ABCA7, ABCB1, ABCG2, ACE, ADAD1, ADRB2, AFF3, AGER, ANKRD55, ANXA3, APOC1, APOE, ATG5, ATXN2, BACH2, BAG6, BANK1, BCL2, BLK, BRD2, BSN, BTNL2, C1orf106, C1orf81, C5, C6orf10, C6orf26, C6orf27, C6orf47, C9orf72, CASP7, CBLB, CCHCR1, CCL1, CCL11, CCL13, CCL2, CCL21, CCL3, CCL5, CCL7, CCL8, CCR2, CCR5, CCR6, CD14, CD226, CD274, CD28, CD4, CD40, CD40LG, CD58, CD70, CD80, CD86, CDK6, CDK7, CDSN, CFB, CFH, CHI3L1, CHRM3, CIITA, CLEC16A, CR1, CTLA4, CX3CR1, CXCL12, CXCR2, CXCR5, CYP2D6, DBP, DUSP1, EBF1, EDIL3, EHMT2, ERAP1, ERBB3, ESR1, EXOC5, F2, FAM167A, FAS, FASLG, FCGR2A, FCGR2B, FCGR3A, FCGR3B, FCRL3, FOXP3, GC, GHRL, GHSR, GIMAP5, GNB3, GSTM1, GSTP1, GSTT1, GYPC, HAPLN1, HAVCR1, HFE, HHAT, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-G, HMHA1, HMOX1, HSPA1A, HSPA1L, HSPD1, HTR2A, ICAM1, ICOS, IFIH1, IFNAR1, IFNB1, IFNG, IFNGR1, IFNGR2, IL10, IL11RA, IL12A, IL12B, IL12RB1, IL13, IL15, IL17A, IL17F, IL17RA, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1F10, IL1R1, IL1RL1, IL1RN, IL2, IL20, IL21, IL21R, IL23A, IL23R, IL24, IL2RA, IL2RB, IL3, IL36A, IL36B, IL36G, IL36RN, IL37, IL4, IL4R, IL6, IL6ST, IL7, IL7R, IL8, IRF1, IRF4, IRF5, ITGA4, ITGAM, JAK2, KIF21B, KIF5A, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1, LCE3B, LCE3C, LEP, LIF, LILRA3, LOC100506023, LST1, LTA, MAGI3, MBD4, MBP, MEFV, MICA, MICB, MIF, MIR146A, MMEL1, MMP1, MMP12, MMP2, MMP3, MMP7, MMP9, MOG, MPG, MSH5, MST1, MSX2, MTHFR, MTNR1B, MTRR, MYO9B, NAMPT, NAT1, NAT2, NCF1, NFKB1, NFKBIA, NFKBIL1, NLRP1, NLRP3, NOD1, NOD2, NOS2, NOS3, NOTCH4, NQO1, NR3C1, NRM, OAS1, OAS3, OGG1, OLIG3, OPCML, OPN1LW, OR2H1, OR2H2, OSMR, P2RX7, PADI2, PADI4, PARP1, PBMUCL1, PDCD1, PECAM1, PLAT, PLAU, PLCG1, PLCL2, PON1, POU5F1, PPARG, PPT2, PRDM1, PRF1, PRKRA, PRL, PRRC2A, PSMB8, PSMB9, PTGER4, PTGS2, PTPN22, PTPRC, PTPRT, PXK, RAD51B, RAGE, RDBP, REL, RETN, RFC1, RGS1, RUNX1, SELE, SELL, SERPINE1, SH2B3, SH2D2A, SLC11A1, SLC19A1, SLC22A4, SLC44A4, SOCS1, SOCS3, SOD1, SPP1, STAT1, STAT2, STAT3, STAT4, SYK, TAGAP, TAP1, TAP2, TGFB1, TIMMDC1, TLR1, TLR10, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TNFAIP3, TNFRSF10A, TNFRSF14, TNFRSF1A, TNFRSF1B, TNFRSF6B, TNPO3, TNXB, TP53, TPH2, TRAF1, TRB@, TRIM10, TRIM15, TRIM26, TRIM31, TRIM40, TRIM5, TSHR, TYK2, UCP2, UGT2B17, UNC13D, VARS2, VAV2, VCAM1, VDR, VEGFA, XRCC1
PSORIATIC ARTHRITIS MULTIPLE SCLEROSIS 4.55e-34 ABCG2, ACE, AFF3, AGER, BAG6, BRD2, BTNL2, C6orf10, C6orf26, C6orf27, C6orf47, CCHCR1, CCL21, CCR2, CCR5, CD28, CDSN, CFB, CTLA4, EHMT2, ERAP1, FCGR2A, FCGR3A, FGF1, GABBR1, GTF2H4, HFE, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-F, HLA-G, HSPA1A, HSPA1B, HSPA1L, IER3, IFNG, IL10, IL12A, IL12B, IL12RB1, IL13, IL17A, IL17RA, IL1A, IL1B, IL1R1, IL1RN, IL2, IL23A, IL23R, IL28RA, IL36A, IL36RN, IL37, IL4, IL4R, IL6, IL8, KIF5A, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1, LCE3B, LCE3C, LST1, LTA, MEFV, MICA, MICB, MIR146A, MOG, MSH5, MTHFR, NFKB1, NFKBIA, NFKBIL1, NLRP3, NOD2, NOS2, NOTCH4, NRM, OR12D3, OR2H1, OR2H2, POU5F1, PPARG, PPT2, PRRC2A, PSMB8, PSMB9, PTPN22, RDBP, REL, RFC1, RNF39, RUNX1, SLC22A4, SLC44A4, STAT3, STAT4, TAP1, TAP2, TNF, TNFAIP3, TNFRSF10A, TNFRSF1A, TNFRSF1B, TNXB, TP53, TRIM10, TRIM15, TRIM26, TRIM31, TRIM40, UBD, VARS2, VDR, VEGFA
ANKYLOSING SPONDYLITIS MULTIPLE SCLEROSIS 1.18e-33 ACE, BTNL2, C1orf106, C1orf81, C6orf47, CAST, CCL2, CCL7, CCR6, CD14, CD274, CTLA4, CYP2D6, DBP, EDIL3, ERAP1, FCGR2B, FCRL3, GC, HAPLN1, HHAT, HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, HSPA1A, IL10, IL12B, IL17RA, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1F10, IL1R1, IL1RN, IL23R, IL2RA, IL36A, IL36B, IL36G, IL36RN, IL37, IL4, IL6, JAK2, KIF21B, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1, LTA, MEFV, MICA, MMP2, MMP3, MSH5, MST1, MSX2, MTHFR, NFKB1, NFKBIA, NLRP1, NLRP3, NOD2, NOS3, PADI4, PBMUCL1, PDCD1, PRKRA, PSMB8, PSMB9, PTGER4, PTPN22, STAT3, STAT4, TAP1, TAP2, TGFB1, TLR2, TLR4, TLR8, TLR9, TNF, TNFRSF1A, TNFRSF1B, TRIM31, TSHR, UGT2B17, VDR, VEGFA
PROTEINURIA MULTIPLE SCLEROSIS 4.66e-24 1231, 6775094, ABCB1, ACE, ADRB2, AFF3, AGER, AGT, APOA1, APOC1, APOE, BANK1, BCL2, BDKRB2, BDNF, BLK, CASP3, CASP8, CCL1, CCL2, CCL3, CCL5, CCL7, CCR2, CCR5, CD14, CFH, CIITA, CTLA4, CX3CR1, CYP3A4, DRD3, EDIL3, ERAP1, ESR1, F2, FCGR2A, FCGR3A, FCGR3B, FOXP3, FRMD3, FTO, GLO1, GNB3, GPC5, GRN, GSTM1, GSTP1, GSTT1, HFE, HLA-A, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, HMOX1, HTR2A, ICAM1, IFNG, IL10, IL12A, IL13, IL18, IL1A, IL1B, IL1R1, IL1RN, IL21, IL3, IL4, IL4R, IL5, IL6, IL7, IL7R, IL8, IRF5, ITGAM, KCNQ1, LEP, LEPR, LTA, MCTP2, MEFV, MIF, MMP12, MMP7, MMP9, MPO, MT-TL1, MTHFR, NGF, NGFR, NOS2, NOS3, NQO1, NR3C1, PDCD1, PIP5K1B, PON1, PON2, PPARG, PTPN22, PXK, RAGE, RGMA, SELE, SELP, SERPINE1, SOD1, SPP1, STAT1, STAT4, TGFB1, TLR10, TLR2, TLR4, TLR9, TNF, TNFRSF1B, TP53, VDR, VEGFA
OPTIC NEURITIS MULTIPLE SCLEROSIS 9.05e-14 APOE, AQP4, CD226, CD58, CD6, CNR1, CYP7A1, GPC5, GSTM1, GSTT1, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL12A, IL17A, IL18, IL2RA, IL7R, IRF8, NFKBIL1, NOTCH4, OPA1, PAFAH1B1, PDCD1, PTPN22, TNF, TNFRSF1A
POLYMYOSITIS MULTIPLE SCLEROSIS 1.05e-08 BLK, CCL2, CCL21, FAM167A, HFE, HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFIH1, IFNG, IL10, IL1A, IL1B, IL4, IL6, IRF5, PTPN22, STAT4, TNF, TNFAIP3
STEVENS-JOHNSON SYNDROME MULTIPLE SCLEROSIS 1.15e-07 ABCB1, BAG6, CYP3A4, FAS, FASLG, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HSPA1A, HSPA1L, IFNG, IL13, IL4, IL4R, NAT2, NFKBIZ, TLR2, TLR3, TLR9, TNF

Chemical, Pharmacological and Biological Annotations


ATC Code:
H01AA01
Brand:
Acthar Gel
Categories:
Hormones; Diagnostic Agents
KEGG Drug ID:
D00146
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
Pharmacodynamics:
Corticotropin acts through the stimulation of cell surface ACTH receptors, which are primarily located on the adrenocortical cells. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly...
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Description:
Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Mechanism:
As a diagnostic aid (adrenocortical function), corticotropin combines with a specific receptor on the adrenal cell plasma membrane. In patients with normal adrenocortical function, it stimulates the initial reaction involved in the synthesi...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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