Rx00079 - Dapsone


Name:
Dapsone
Rx ID:
Rx00079
Validation Level:
Phenomic Similarity:
0.542
Reference ID:
DB00250
Primary Indications:
Toxoplasmosis; immunodeficiency; Pneumocystis carinii pneumonia
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Dermatitis herpetiformis; acne vulgaris
Drug Interactions:
Aluminium; Calcium; Lumefantrine; Magnesium; Magnesium oxide; Rifabutin; Rifampicin; Telithromycin; Tolbutamide; Trimethoprim; ...
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Food Interactions:
Take without regard to meals.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00079
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
immunodeficiency acne vulgaris 23 846 16665 6.582 5.52E-12 1.77e-08
pneumocystis carinii pneumonia acne vulgaris 20 745 16665 6.5 1.59E-10 5.1e-07

Chemical, Pharmacological and Biological Annotations


ATC Code:
D10AX05 J04BA02;
Categories:
Antimalarials; Folic Acid Antagonists; Anti-Infective Agents; Leprostatic Agents; Antimycobacterials
ChEBI ID:
4325
PubChem ID:
2955
KEGG Drug ID:
D00592
SMILE:
NC1=CC=C(C=C1)S(=O)(=O)C1=CC=C(N)C=C1
InChI:
1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
Classification:
Kingdom:
Organic Compounds
Superclass:
Benzenoids
Class:
Benzene and Substituted Derivatives
Subclass:
Anilines
Indication:
For the treatment and management of leprosy and dermatitis herpetiformis.
Pharmacodynamics:
Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Dapsone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment...
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Description:
A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in...
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Mechanism:
Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibiting the synthesis of dihydrofolic acid through competition with para-amino-benzoate for the active site of dihydropteroate synthetase. The anti-i...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
High CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.3635 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org