Rx00082 - Dexamethasone


Name:
Dexamethasone
Rx ID:
Rx00082
Validation Level:
Phenomic Similarity:
0.509
Reference ID:
DB01234
Primary Indications:
Corneal graft rejection; ocular inflammation; panuveitis
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Palpebral conjunctiva; bulbar conjunctiva; allergic conjunctivitis; acne rosacea; superficial punctate keratitis; herpes zoster keratitis; iritis; cyclitis; infective conjunctivitis; edema; inflammation; corneal injury; allergic otitis externa; purulent infective otitis externa; nonpurulent infective otitis externa
Pathways:
Prostaglandin Synthesis and Regulation; Spinal Cord Injury; corticosteroids and cardioprotection; Serotonin Receptor 4-6-7 and NR3C Signaling; Regulation of Androgen receptor activity
Drug Interactions:
Acenocoumarol; Acetylsalicylic acid; Ambenonium; Aminoglutethimide; Amobarbital; Anisindione; Aprepitant; Aprobarbital; Asparaginase Erwinia chrysanthemi; Butabarbital; ...
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Food Interactions:
Avoid alcohol. Avoid taking with grapefruit juice. Take with food to reduce irritation.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00082
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
ocular inflammation cyclitis 2723 2723 2723 1481.794 0 0.0
panuveitis cyclitis 32 64 2723 740.897 1.16E-76 3.72e-73
corneal graft rejection allergic conjunctivitis 10 73 16138 34.25 1.89E-12 6.05e-09

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
PANUVEITIS EDEMA 1.07e-14 6775098, ABCB1, ABO, ACE, APOE, C4A, C4B, CASP1, CCL2, CCL5, CCR1, CCR5, CD14, CD40, CFB, CFH, CPB2, CTLA4, CXCR1, CXCR2, CYP1A1, CYP24A1, CYP27B1, CYP2C19, CYP2C9, DARC, DHCR7, ERAP1, F2, F5, FCGR2A, FCGR3A, FCGR3B, FOXO1, GSTM1, GSTT1, HLA-A, HLA-B, HLA-DMA, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-G, HTRA1, ICAM1, ICOSLG, IFNA1, IFNAR1, IFNAR2, IFNG, IL10, IL12A, IL12B, IL12RB2, IL13, IL17F, IL18, IL1A, IL1B, IL1R1, IL1RN, IL2, IL23R, IL2RA, IL4, IL4R, IL6, IL6R, IL8, IRF5, ITGA2, ITGB3, JAK1, JAK2, LEP, LTA, MBL2, MEFV, MICA, MIF, MMP12, MMP2, MMP9, MPO, MTHFR, NAT2, NFKB1, NFKBIA, NLRP3, NOD2, NOS2, NOS3, NRG1, P2RX7, PON1, PROCR, PROZ, PSORS1C1, PTPN22, ROCK1, ROCK2, RUNX1, SERPINE1, SLC11A1, SLC22A5, SOD2, SOD3, SPP1, STAT3, TAP1, TAP2, TGFB1, TGFBR1, TGFBR3, TIMP2, TIRAP, TLR2, TLR4, TLR7, TLR8, TLR9, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TREM1, TYMS, VDR, VEGFA

Chemical, Pharmacological and Biological Annotations


ATC Code:
A01AC02; C05AA09; D07AB19; D07XB05; D10AA03; H02AB02; R01AD03; S01BA01; S01CB01; S02BA06 S03BA01;
Brand:
Decadron (Sidus)
Categories:
Antineoplastic Agents, Hormonal; Anti-Inflammatory Agents; Glucocorticoids; Antiemetics
ChEBI ID:
41879
PubChem ID:
5743
KEGG Drug ID:
D00292
SMILE:
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
InChI:
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Lipids
Class:
Steroids and Steroid Derivatives
Subclass:
Gluco/mineralocorticoids, Progestogins and Derivatives
Indication:
<B>Injection:</B> for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neop...
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Pharmacodynamics:
Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is use...
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Description:
An anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]
Mechanism:
Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) whi...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.1482 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Inhibitor

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org