Rx00083 - Dextran


Name:
Dextran
Rx ID:
Rx00083
Validation Level:
Phenomic Similarity:
0.567
Reference ID:
DB00893
Primary Indications:
Cystic fibrosis; recurrent corneal erosion
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Anaphylaxis; hypovolemic shock
Pathways:
Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; O2/CO2 exchange in erythrocytes
Drug Interactions:
Alendronate; Ciprofloxacin; Clodronate; Deferiprone; Demeclocycline; Doxycycline; Eltrombopag; Enoxacin; Etidronic acid; Gatifloxacin; ...
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Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00083
Primary Indication
Secondary Indication

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
CYSTIC FIBROSIS ANAPHYLAXIS 2.13e-07 ACE, AGT, CD14, FCGR2A, HLA-B, HLA-DQB1, HLA-DRB1, IL10, IL18, IL4, IL4R, TGFB1

Chemical, Pharmacological and Biological Annotations


ATC Code:
No ATC code annotated in DrugBank
Brands:
CosmoFer (B. Braun); Feosol (GlaxoSmithKline); Imferon (Sanofi-Aventis); Proferdex (New River Pharmaceuticals Inc.)
Categories:
Hematinics; Anti-anemic Agents; Supplements
KEGG Drug ID:
D02141
Indication:
For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or ...
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Pharmacodynamics:
Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsat...
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Description:
Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administrat...
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Mechanism:
After iron dextran is injected, the circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the availa...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org