Rx00086 - Dimethyl Sulfoxide


Name:
Dimethyl Sulfoxide
Rx ID:
Rx00086
Validation Level:
Phenomic Similarity:
0.564
Reference ID:
DB01093
Primary Indications:
Scleroderma; intracranial pressure; head injury; traumatic brain coma; soft tissue injury; palmar-plantar erythrodysesthesia syndrome; drug resistant tuberculosis
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Interstitial cystitis
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

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Interactive Bipartite Drug Repurposing Graph

Rx00086
Primary Indication
Secondary Indication

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Chemical, Pharmacological and Biological Annotations


ATC Code:
G04BX13 M02AX03;
Categories:
Free Radical Scavengers; Solvents; Cryoprotective Agents
ChEBI ID:
28262
PubChem ID:
679
KEGG Drug ID:
D01043
SMILE:
CS(C)=O
InChI:
1S/C2H6OS/c1-4(2)3/h1-2H3
Classification:
Kingdom:
Organic Compounds
Superclass:
Organosulfur Compounds
Class:
Sulfoxides
Subclass:
Indication:
For the symptomatic relief of patients with interstitial cystitis.
Pharmacodynamics:
Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substa...
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Description:
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during...
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Mechanism:
The mechanism of dimethyl sulfoxide's actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
0.7619 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org