Rx00087 - Doripenem


Name:
Doripenem
Rx ID:
Rx00087
Validation Level:
Reference ID:
CHEMBL491571
Primary Indications:
Bronchopulmonary infection; cystic fibrosis
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Intra-abdominal infections; urinary tract infections; pyelonephriti
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00087
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
bronchopulmonary infection urinary tract infections 34 637 61965 3.476 2.02E-09 6.48e-06

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
CYSTIC FIBROSIS URINARY TRACT INFECTIONS 2.56e-17 ACE, AGT, CD14, CXCR1, CXCR2, GSTM1, GSTT1, HSPA1B, ICAM1, IL10, IL4, IL6, IL8, LTA, NQO1, TGFB1, TLR1, TLR2, TLR4, TLR5, TLR6, TNF, VDR

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org