Rx00089 - Doxorubicin


Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00089
Primary Indication
Secondary Indication

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
ovarian cancer ovarian carcinoma 5625 5625 5625 717.32 0 0.0
primary breast cancer resection breast carcinoma 22462 22462 22462 179.633 0 0.0
Hodgkin's disease malignant lymphoma 552 1346 4708 351.474 0 0.0
acute myeloblastic leukemia acute lymphoblastic leukemia 226 941 1823 531.579 0 0.0
AIDS Kaposi's Sarcoma 206 11821 432 162.766 0 0.0
malignant lymphoma Hodgkin's disease 552 4708 1346 351.474 0 0.0
acute lymphoblastic leukemia acute myeloblastic leukemia 226 1823 941 531.579 0 0.0
bronchogenic carcinoma breast carcinoma 434 5146 22462 15.15 0 0.0
ovarian carcinoma ovarian cancer 5625 5625 5625 717.32 0 0.0
Kaposi's sarcoma Kaposi's Sarcoma 432 432 432 9340.102 0 0.0
multiple myeloma malignant lymphoma 238 3327 4708 61.309 4.62939510153e-320 1.4864987671e-316
Wilms' tumor transitional cell bladder carcinoma 160 2284 3208 88.11 1.03E-240 3.3e-237
bone sarcomas breast carcinoma 103 1479 22462 12.51 1.43E-72 4.59e-69
gastric carcinoma gastric cancer 26 63 1717 969.835 5.49E-66 1.76e-62
neuroblastoma ovarian cancer 20 286 5625 50.162 5.99E-27 1.92e-23

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
ACUTE MYELOBLASTIC LEUKEMIA ACUTE LYMPHOBLASTIC LEUKEMIA 9.61e-193 3807, ABCB1, ABCC1, ABCC3, ABCG2, ABHD16A, ACAA1, ACAD11, ADAM19, ADAP1, AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, ALOX5AP, ALOXE3, APEX1, APOA2, ARID5B, ASXL1, ATG9B, ATM, BAK1, BAX, BCL2, BPI, BRCA2, BRD7, C1D, C1QA, C1QB, C1QBP, C1QC, C1RL, C1S, C2, C3, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CBL, CCL1, CCL11, CCL13, CCL18, CCL2, CCL20, CCL24, CCL26, CCL5, CCL7, CCL8, CCR1, CCR3, CCR4, CCR6, CCR7, CCR8, CCR9, CD14, CD180, CD209, CD46, CD55, CD93, CDA, CDKN1A, CDKN2A, CDKN2B, CDKN2B-AS1, CEBPA, CEBPE, CFB, CLCA1, CLCA2, CNTNAP1, CORO1C, CRP, CTLA4, CTNNB1, CXCL10, CXCL12, CXCR1, CXCR2, CYBA, CYP1A1, CYP21A2, CYP2B6, CYP2D6, CYP2E1, CYP3A4, DAB2, DCK, DDR1, DEF6, DEFA3, DEFA4, DEFA5, DEFA6, DEFB1, DEFB118, DEFB119, DEFB126, DEFB127, DHFR, DHX33, DLG5, DNMT3A, DOK2, EPHX1, EPO, ERCC1, ERCC2, ETV6, F5, FAS, FASLG, FCER1A, FCER1G, FCER2, FCGR2A, FCGRT, FGF2, FLJ90680, FLT3, FOXJ2, GGCT, GLS, GPR108, GPR44, GSTM1, GSTO2, GSTP1, GSTT1, HES7, HGF, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-G, HSPA6, ICAM1, ICAM2, ICAM3, ICAM4, ICAM5, IDH1, IDH2, IKZF1, IL10, IL11RA, IL17C, IL6, IL8, INSL3, IRAK2, IRAK3, IRAK4, ITGB2, JAK1, JAK2, JAK3, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, KIT, KLK1, KLK15, KLK2, KLK4, KLK6, KLK7, KLKB1, KRAS, LBP, LMAN1, LPO, LTA, LTBR, LY6G6D, LY96, MAL, MASP1, MASP2, MBL2, MBP, MDM2, MEFV, MIF, MLH1, MLL, MPO, MTAP, MTHFR, MTR, MUC6, MUC7, MYD88, NAB2, NAT1, NAT2, NBN, NCF2, NCF4, NDUFS2, NF1, NF2, NFKB1, NIPAL4, NOD1, NOD2, NOS1, NOS2, NOS3, NOTCH1, NQO1, NRAS, NUDT6, OR10J3, PDCD10, PFKFB2, PHF6, PIM1, PML, PTGDR, PTGS2, PTPN11, RAC1, RAC2, RAD51, RASA1, RAVER1, RPS4XP13, RUNX1, SCAF4, SCGB1A1, SCNN1A, SECTM1, SELE, SELP, SELPLG, SENP3, SERPINB2, SERPINB3, SERPINC1, SERPINE1, SERPING1, SERPINI1, SHMT1, SLC2A11, SLCO1B1, SOCS1, SOCS2, SOCS3, SOCS4, SOD1, SOD2, SOD3, SPI1, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STK19, TERC, TERT, TET2, TICAM1, TLR1, TLR10, TLR2, TLR3, TLR4, TLR6, TLR9, TMCO6, TNFRSF18, TNFSF18, TNFSF9, TOLLIP, TOP2A, TP53, TPMT, TRAM1, TSLP, TWF1, TWF2, TYK2, TYMS, VCAM1, VEGFA, WDHD1, WT1, XDH, XPA, XPC, XRCC1, XRCC3, XRCC4, ZNF76, ZP1
ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MYELOBLASTIC LEUKEMIA 9.61e-193 3807, ABCB1, ABCC1, ABCC3, ABCG2, ABHD16A, ACAA1, ACAD11, ADAM19, ADAP1, AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, ALOX5AP, ALOXE3, APEX1, APOA2, ARID5B, ASXL1, ATG9B, ATM, BAK1, BAX, BCL2, BPI, BRCA2, BRD7, C1D, C1QA, C1QB, C1QBP, C1QC, C1RL, C1S, C2, C3, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CBL, CCL1, CCL11, CCL13, CCL18, CCL2, CCL20, CCL24, CCL26, CCL5, CCL7, CCL8, CCR1, CCR3, CCR4, CCR6, CCR7, CCR8, CCR9, CD14, CD180, CD209, CD46, CD55, CD93, CDA, CDKN1A, CDKN2A, CDKN2B, CDKN2B-AS1, CEBPA, CEBPE, CFB, CLCA1, CLCA2, CNTNAP1, CORO1C, CRP, CTLA4, CTNNB1, CXCL10, CXCL12, CXCR1, CXCR2, CYBA, CYP1A1, CYP21A2, CYP2B6, CYP2D6, CYP2E1, CYP3A4, DAB2, DCK, DDR1, DEF6, DEFA3, DEFA4, DEFA5, DEFA6, DEFB1, DEFB118, DEFB119, DEFB126, DEFB127, DHFR, DHX33, DLG5, DNMT3A, DOK2, EPHX1, EPO, ERCC1, ERCC2, ETV6, F5, FAS, FASLG, FCER1A, FCER1G, FCER2, FCGR2A, FCGRT, FGF2, FLJ90680, FLT3, FOXJ2, GGCT, GLS, GPR108, GPR44, GSTM1, GSTO2, GSTP1, GSTT1, HES7, HGF, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-G, HSPA6, ICAM1, ICAM2, ICAM3, ICAM4, ICAM5, IDH1, IDH2, IKZF1, IL10, IL11RA, IL17C, IL6, IL8, INSL3, IRAK2, IRAK3, IRAK4, ITGB2, JAK1, JAK2, JAK3, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, KIT, KLK1, KLK15, KLK2, KLK4, KLK6, KLK7, KLKB1, KRAS, LBP, LMAN1, LPO, LTA, LTBR, LY6G6D, LY96, MAL, MASP1, MASP2, MBL2, MBP, MDM2, MEFV, MIF, MLH1, MLL, MPO, MTAP, MTHFR, MTR, MUC6, MUC7, MYD88, NAB2, NAT1, NAT2, NBN, NCF2, NCF4, NDUFS2, NF1, NF2, NFKB1, NIPAL4, NOD1, NOD2, NOS1, NOS2, NOS3, NOTCH1, NQO1, NRAS, NUDT6, OR10J3, PDCD10, PFKFB2, PHF6, PIM1, PML, PTGDR, PTGS2, PTPN11, RAC1, RAC2, RAD51, RASA1, RAVER1, RPS4XP13, RUNX1, SCAF4, SCGB1A1, SCNN1A, SECTM1, SELE, SELP, SELPLG, SENP3, SERPINB2, SERPINB3, SERPINC1, SERPINE1, SERPING1, SERPINI1, SHMT1, SLC2A11, SLCO1B1, SOCS1, SOCS2, SOCS3, SOCS4, SOD1, SOD2, SOD3, SPI1, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STK19, TERC, TERT, TET2, TICAM1, TLR1, TLR10, TLR2, TLR3, TLR4, TLR6, TLR9, TMCO6, TNFRSF18, TNFSF18, TNFSF9, TOLLIP, TOP2A, TP53, TPMT, TRAM1, TSLP, TWF1, TWF2, TYK2, TYMS, VCAM1, VEGFA, WDHD1, WT1, XDH, XPA, XPC, XRCC1, XRCC3, XRCC4, ZNF76, ZP1
MALIGNANT LYMPHOMA ACUTE LYMPHOBLASTIC LEUKEMIA 3.9e-155 ABCB1, ABCC1, ABCC2, ABCC3, ABCG2, ABHD16A, ABL1, ACAA1, ACAD11, ACP1, ADAM19, ADAP1, ADRB2, AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, ALOX5AP, ALOXE3, APEX1, APOA2, APOB, ARHGAP24, ARID5B, ARNT, ASXL1, ATG9B, ATM, BAD, BAK1, BAX, BCL2, BCL2L1, BCL2L11, BHMT, BID, BPI, BRAF, BRCA2, C1D, C1QA, C1QB, C1QBP, C1QC, C1RL, C1S, C2, C3, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CASP8, CAT, CBS, CCL1, CCL11, CCL13, CCL18, CCL2, CCL20, CCL24, CCL26, CCL5, CCL7, CCL8, CCND1, CCR1, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD14, CD180, CD209, CD28, CD40, CD46, CD55, CD80, CD93, CDA, CDK4, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2B-AS1, CEBPA, CFB, CLCA1, CLCA2, CNTNAP1, COL1A1, CORO1C, CRP, CTLA4, CTNNB1, CXCL12, CXCR1, CXCR2, CYBA, CYP1A1, CYP1A2, CYP1B1, CYP21A2, CYP2B6, CYP2C19, CYP2C8, CYP2D6, CYP2E1, CYP3A4, CYP3A5, DAB2, DCK, DEF6, DEFA3, DEFA4, DEFA5, DEFA6, DEFB1, DEFB118, DEFB119, DEFB126, DEFB127, DHFR, DHX33, DLG5, DNMT3A, DPYD, DROSHA, EPHX1, ERCC1, ERCC2, ERCC4, ESR1, ETV6, F2, F5, FAS, FASLG, FBXW7, FCER1A, FCER1G, FCER2, FCGR2A, FCGRT, FGF2, FHIT, FLT3, FOXJ2, FPGS, GATA3, GGCT, GGH, GHRL, GLS, GPR108, GPR44, GSTM1, GSTM3, GSTP1, GSTT1, HES7, HFE, HGF, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-G, HPSE, HRAS, HSPA6, ICAM1, ICAM2, ICAM3, ICAM4, ICAM5, IDH1, IDH2, IGF1, IGF1R, IGF2, IGF2R, IKZF1, IL10, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL15, IL16, IL17C, IL1RN, IL2, IL4, IL4R, IL6, IL7R, IL8, INSL3, IRAK2, IRAK3, IRAK4, IRF4, IRF8, ITGB2, JAK1, JAK2, JAK3, KCNIP4, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, KIT, KLK1, KLK15, KLK2, KLK4, KLK6, KLK7, KLKB1, KRAS, LBP, LEF1, LEP, LEPR, LMAN1, LPO, LTA, LTBR, LY6G6D, LY96, LYN, MAL, MASP1, MASP2, MBL2, MBP, MCL1, MDM2, MEFV, MGMT, MIF, MIR146A, MIR196A2, MIR499, MLH1, MPO, MS4A2, MSH3, MTAP, MTHFD1, MTHFR, MTOR, MTR, MTRR, MUC6, MUC7, MYD88, NAB2, NAT1, NAT2, NBN, NCF2, NCF4, NDUFS2, NFKB1, NFKBIA, NFKBIB, NIPAL4, NOD1, NOD2, NOS1, NOS2, NOS3, NOTCH1, NPY, NQO1, NR3C1, NRAS, NUDT6, OGG1, OR10J3, PARD3B, PARP1, PDCD10, PFKFB2, PIK3CA, PIM1, PON1, PPP1R13L, PRF1, PTGDR, PTGS2, RAC1, RAC2, RAD51, RAG1, RAG2, RASGRP1, RAVER1, RB1, RFC1, SCAF4, SCGB1A1, SCNN1A, SECTM1, SELE, SELP, SELPLG, SENP3, SERPINB2, SERPINE1, SERPING1, SETD8, SHMT1, SLC13A1, SLC19A1, SLC2A11, SLCO1B1, SLCO1B3, SOCS1, SOCS2, SOCS3, SOCS4, SOD1, SOD2, SOD3, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STK19, SYK, TCF3, TCF4, TERC, TERT, TET2, TGFB1, TGFBR1, TICAM1, TLR1, TLR10, TLR2, TLR3, TLR4, TLR6, TLR9, TMCO6, TNF, TNFRSF18, TNFRSF1A, TNFRSF1B, TNFSF18, TNFSF9, TOLLIP, TOP2A, TP53, TPMT, TRAM1, TSLP, TWF1, TWF2, TYK2, TYMS, UGT1A1, VCAM1, VDR, VEGFA, WDHD1, WT1, XDH, XPA, XPC, XRCC1, XRCC3, XRCC4, ZNF76, ZP1
MULTIPLE MYELOMA MALIGNANT LYMPHOMA 2.83e-124 ABCA1, ABCB1, ABCC1, ABCC2, ABCC3, ABCF2, ABCG2, ABP1, AFF1, AHR, ALDH1A1, ANKRD55, B4GALT1, BAX, BIRC2, BRAF, CARD11, CASP10, CASP3, CASP8, CASP9, CBX7, CCND1, CCR7, CD27, CD28, CD3EAP, CD4, CD40, CD5, CD70, CD79B, CD81, CDKN1A, CDKN2A, CDKN2C, CEBPA, CETP, CFLAR, CHST11, CHUK, CINP, COL18A1, COL1A1, CROT, CTLA4, CTSS, CXCL12, CXCR2, CXCR4, CYP17A1, CYP1A1, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, CYP3A5, DERL3, DIS3, DNAH11, DNAJC16, DTNB, DYNC1I1, EPHA3, EPHB2, EPHX1, ERCC1, ERCC2, ERCC5, F2, F5, FADD, FAM179B, FAM46C, FAS, FASLG, FCGR2A, FCGR3A, FCGR3B, FDPS, FLT3, FUT8, GAN, GBA, GJE1, GSK3B, GSTM1, GSTP1, GSTT1, GYS1, HAS1, HFE, HGF, HLA-C, HLA-DPB1, HLA-DQB1, HLA-DRB1, HPSE, ICAM1, ICAM4, ICAM5, IFNG, IGF1, IGF1R, IGFBP1, IGFBP2, IGFBP3, IKBKB, IKZF1, IL10, IL10RA, IL10RB, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL15, IL18, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RN, IL2, IL4, IL4R, IL5, IL6, IL6R, IL6ST, IL8, IL9, IRF4, IRS1, IRS2, ITGA6, JAK1, JAK3, KDR, KIR2DS4, KIR2DS5, KRAS, KRT81, LIG4, LMTK2, LTA, LTBR, MBL2, MEFV, MGAT3, MIR196A2, MMP2, MPO, MTHFR, MTR, MTRR, MYD88, MYNN, NAIP, NAT1, NAT2, NFKB1, NFKB2, NFKBIA, NFKBIE, NFRKB, NOS3, NOTCH1, NQO1, NR1I2, NR1I3, NRAS, P2RX7, P2RY2, PDGFRA, PON1, PPARD, PPARG, PPP1R13L, PSMA6, PSMB1, PSORS1C1, PSORS1C2, PTGS2, RAG1, RAG2, RB1, REL, RELA, RELB, RPS19, SERPINB2, SERPINE1, SLC12A6, SLC3A2, SLC7A5, SLC7A8, SMARCB1, SMARCD3, SPP1, ST6GAL1, SULT1C2, SUV420H1, TANK, TAP1, TAP2, TARBP2, TCF4, TERC, TERT, TGFB1, TLR1, TLR10, TLR2, TLR4, TLR6, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF1A, TNFRSF1B, TNFRSF25, TNFRSF8, TNFRSF9, TNFSF10, TNFSF13B, TNFSF14, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TOP2A, TP53, TRADD, TRAF2, TRAF3, TRAF5, TRAF6, TYMS, ULK4, VCAM1, VDR, VEGFA, XPA, XPO5, XRCC1, XRCC3, XRCC4, XRCC5
HODGKIN'S DISEASE MALIGNANT LYMPHOMA 1.14e-109 ABCB1, AICDA, APEX1, ATM, BAX, BCL10, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L2, BCL6, BCL7A, BCL7C, BLM, BLMH, BMF, BRCA1, BRCA2, CASP1, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP8AP2, CASP9, CCL17, CCND1, CCNH, CD14, CD28, CD4, CD40, CD5, CD70, CD79A, CD79B, CD81, CFLAR, CHEK2, CHUK, CXCL12, CXCR1, CXCR2, CYP1A1, CYP2C9, CYP2D6, CYP2E1, CYP3A4, EOMES, EPHX1, ERAP1, ERCC1, ERCC2, ERCC3, ERCC5, ERCC6, FADD, FAS, FASLG, FCGR2A, FGFR2, GATA3, GPX1, GPX2, GPX3, GPX4, GSTA1, GSTM1, GSTP1, GSTT1, HBS1L, HCG9, HFE, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HPSE, ICAM1, IFNG, IKBKB, IL10, IL10RA, IL10RB, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL15, IL18, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RN, IL2, IL4, IL4R, IL5, IL6, IL6R, IL6ST, IL8, IL9, IRF4, ITGA6, JAK3, KRT81, LIG1, LIG3, LIG4, LMO2, LMTK2, LTA, LTC4S, MDM2, MGMT, MICB, MLH1, MRE11A, MS4A2, MTHFR, MTR, MYB, MYC, MYD88, NBN, NFKB1, NFKB2, NFKBIA, NFKBIE, NFRKB, NQO1, OGG1, PARP1, PIM1, POLB, PPARG, PRKDC, PTGS2, PTPN1, PVT1, RAD50, RAD51, RAD54L, RAG1, RAG2, REL, RELA, RELB, RIPK1, RIPK2, RPL13P2, SHMT1, SOCS1, STAT1, STAT3, STAT5A, STAT6, TANK, TARBP2, TERT, TGFB1, TLR1, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR8, TLR9, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF18, TNFRSF9, TNFSF10, TNFSF13, TNFSF14, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TP53, TP53I3, TRADD, TRAF2, TRAF5, TRAF6, TYMS, UGT1A1, UGT1A6, VCAM1, VEGFA, WRN, XPC, XPO5, XRCC1, XRCC2, XRCC3, XRCC4
OVARIAN CANCER OVARIAN CARCINOMA 2.19e-18 ANKLE1, BABAM1, BRIP1, CHMP4C, HNF1B, LOC401022, MLLT10, SKAP1, TIPARP
OVARIAN CARCINOMA OVARIAN CANCER 2.19e-18 ANKLE1, BABAM1, BRIP1, CHMP4C, HNF1B, LOC401022, MLLT10, SKAP1, TIPARP
NEUROBLASTOMA ACUTE MYELOBLASTIC LEUKEMIA 2.34e-17 ABCC1, ACE, CEBPA, CTNNB1, CYP3A4, DAB2, FAS, FASLG, FCGR2A, FCGR3A, FLT3, GATA1, GSTM1, GSTP1, GSTT1, HLA-A, HLA-B, HLA-C, IL6, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DS1, KRAS, MDM2, MLL, MTHFR, MTR, NAT1, NBN, NQO2, NRAS, NTRK1, RASA1, SOD1, TP53, TYMS, VEGFA

Chemical, Pharmacological and Biological Annotations


ATC Code:
L01DB01
Brands:
Adriablastina (Pfizer); Adriamycin (Pfizer); Adriblastin (Actavis); Rubex
Categories:
Antibiotics, Antineoplastic; Antibiotics
ChEBI ID:
28748
PubChem ID:
31703
KEGG Drug ID:
D03899
SMILE:
COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C(=O)CO)C(O)=C1C2=O
InChI:
1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Phenylpropanoids and Polyketides
Class:
Anthracyclines
Subclass:
Indication:
Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma,...
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Pharmacodynamics:
Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand break...
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Description:
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA dou...
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Mechanism:
Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
-
Blood Brain Barrier:
-
Caco-2 permeable:
-
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.6644 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org