Rx00094 - Epoetin Alfa


Name:
Epoetin Alfa
Rx ID:
Rx00094
Validation Level:
Phenomic Similarity:
0.483
Reference ID:
DB00016
Primary Indications:
Anemia; renal transplantation; HIV
Orphan Indications:
Myelodysplastic syndrome; preterm infant anemia of prematurity
Rare Indications:
Anemia; chronic renal failure; dialysis
Common Indications:
Anemia; non-myeloid malignancy; chemotherapy; perioperative blood loss
Pathways:
Cytokine-cytokine receptor interaction - Homo sapiens (human); Hematopoietic cell lineage - Homo sapiens (human)
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00094
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

Click row to show all

Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
renal transplantation chronic renal failure 2391 13091 11565 63.723 0 0.0
HIV chronic renal failure 572 11821 11565 16.882 0 0.0
anemia preterm infant anemia of prematurity 109590 109590 109590 36.818 0 0.0

Shared Genetic Architectures of Disease Pairs

Click row to show all

Disease A Disease B Adjusted P-Value Shared Gene IDs
ANEMIA CHRONIC RENAL FAILURE 3.75e-61 1231, ABCB1, ABCC1, ABCC2, ABCC4, ACE, ADAMTS13, ADRB2, AGT, AGTR1, ALDH2, ANK1, APEX1, APOA1, APOB, APOE, APOL1, ATM, ATR, BCL11A, BDKRB2, BLM, BMP2, BMP4, BMPR1A, BRCA1, BRCA2, BTBD9, C4BPA, CARTPT, CCL5, CCR5, CD36, CD81, CD86, CDA, CFH, CFHR1, CFHR3, CHEK1, CHEK2, COMT, CR1, CSF3R, CTLA4, CXCR1, CXCR2, CYBA, CYP1A1, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, DCK, DRD2, EDN1, EGFR, ENPP1, EPHX1, EPO, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ESR1, EXO1, F10, F13A1, F2, F5, F7, FANCA, FANCE, FANCL, FAS, FCGR2A, FGA, FGB, FGFR4, FLNB, FLT4, GATA2, GCLC, GP1BA, GPX1, GSR, GSTA1, GSTM1, GSTM3, GSTP1, GSTT1, HBB, HFE, HIF1A, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-G, HMOX1, HP, HSPA1B, ICAM1, IFNG, IFNGR2, IGF1R, IKBKAP, IL10, IL10RA, IL12A, IL12B, IL12RB2, IL13, IL18, IL1A, IL1B, IL1RN, IL2, IL28B, IL4, IL4R, IL6, IL8, ITGA2, ITGA2B, ITGB3, JAK3, KIR2DL2, KIR2DL3, KIR2DS1, KIR2DS2, KIR2DS3, KIR3DL1, KIR3DS1, KL, KRAS, LDLR, LEP, LIG1, LIG3, LIG4, LTA, MBL2, MGMT, MIF, MLH1, MLH3, MMP2, MMP3, MPO, MRE11A, MSH2, MSH3, MSH6, MTHFR, MTR, MTRR, MUTYH, MYH9, MYLK, NAT2, NBN, NEIL2, NOS2, NOS3, NOTCH1, NQO1, NR1I2, OGG1, PARP1, PCNA, PMS1, PMS2, POLB, POLD1, POLE, POLI, PON1, PPARG, PROCR, PROZ, PTPN22, RAD23B, RAD50, RAD52, RAD54B, RFC1, RRM1, SELE, SELL, SELP, SERPINE1, SERPING1, SLC28A2, SLC28A3, SLC29A1, SLCO1B1, SMAD3, SMAD4, SOD2, SPP1, TCN2, TEK, TGFB1, THBD, TLR2, TLR3, TLR4, TLR9, TNF, TNFRSF1B, TP53, TPMT, UGT1A1, UGT1A10, UGT1A8, UGT2B7, VCAM1, VDR, VEGFA, WT1, XPC, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, XRCC6, ZHX2

Chemical, Pharmacological and Biological Annotations


ATC Code:
B03XA01
Brands:
Binocrit (Sandoz); Epocept (Lupin pharma); Epofit (Intas pharma); Epogin (Chugai); Eprex (Janssen-Cilag. Ortho Biologics LLC); Nanokine (Nanogen Pharmaceutical biotechnology, Vietnam))
Categories:
Hematinics; Anti-anemic Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For treatment of anemia (from renal transplants or certain HIV treatment)
Pharmacodynamics:
Used in the treatment of anemia. Involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Description:
Human erythropoietin (recombinant), produced by CHO cells.
Mechanism:
Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) pro...
Click to show more...

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org