Rx00099 - Etanercept


Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00099
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
plaque psoriasis adult chronic severe plaque psoriasis 6551 6551 6551 615.925 0 0.0
chronic severe plaque psoriasis adult chronic severe plaque psoriasis 6551 6551 6551 615.925 0 0.0
severely active polyarticular juvenile idiopathic arthritis severely active polyarticular-course juvenile rheumatoid arthritis 352 352 352 11462.852 0 0.0
moderately active rheumatoid arthritis severely active rheumatoid arthritis 7378 7378 7378 546.886 0 0.0
severely active rheumatoid arthritis moderately active rheumatoid arthritis 7378 7378 7378 546.886 0 0.0
psoriatic arthritis adult chronic severe plaque psoriasis 516 1275 6551 249.268 0 0.0
chronic moderate severe plaque psoriasis adult chronic severe plaque psoriasis 6551 6551 6551 615.925 0 0.0
active arthritis moderately active rheumatoid arthritis 7378 160544 7378 25.133 0 0.0
moderately active polyarticular juvenile idiopathic arthritis severely active polyarticular-course juvenile rheumatoid arthritis 352 352 352 11462.852 0 0.0
active ankylosing spondylitis active arthritis 206 496 160544 10.438 5.97E-118 1.92e-114

Chemical, Pharmacological and Biological Annotations


ATC Code:
L04AB01
Brand:
Enbrel Sureclick
Category:
Immunosuppressive Agents
KEGG Drug ID:
D00742
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For treatment of severe active rheumatoid arthritis in adults, severe juvenile idiopathic arthritis, ankylosing spondylitis, and severe plaque psoriasis.
Pharmacodynamics:
Tumor necrosis factor TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in tissues and fluids of patients with rheumatoid arthritis, psoriatic arthritis, ank...
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Description:
Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 dom...
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Mechanism:
There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeri...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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Manhattan, New York City, NY
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