Rx00104 - Filgrastim


Name:
Filgrastim
Rx ID:
Rx00104
Validation Level:
Phenomic Similarity:
0.451
Reference ID:
DB00099
Primary Indications:
Acute myeloid leukemia; cancer; bone marrow transplantation; severe chronic neutropenia; severe neutropenia; non-myeloid malignancies
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Myelodysplastic syndrome; cytomegalovirus retinitis; AIDS
Common Indications:
Febrile neutropenia; nonmyeloid malignancies; severe neutropenia with fever; fever; acute myeloid leukemia; neutropenia and neutropenia-related clinical sequelae eg febrile neutropenia nonmyeloid malignancies; myeloablative chemotherapy; marrow transplantation
Drug Interactions:
Bleomycin; Cyclophosphamide Topotecan;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00104
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
severe chronic neutropenia febrile neutropenia 5318 5318 5318 758.73 0 0.0
acute myeloid leukemia myelodysplastic syndrome 225 941 1504 641.476 0 0.0
severe neutropenia febrile neutropenia 5318 5318 5318 758.73 0 0.0

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
ACUTE MYELOID LEUKEMIA FEVER 3.33e-48 ABCB1, ACE, C3, C5AR1, CCL2, CCR1, CCR3, CD14, CD209, CDKN2A, CDKN2B, CFB, CRP, CTLA4, CYP3A4, ERCC1, ERCC2, ETV6, F5, FCGR2A, FLT3, GSTM1, GSTP1, GSTT1, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-G, ICAM1, IL10, IL23R, IL6, IL8, IRAK4, IRF1, JAK1, JAK2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, LTA, MASP2, MBL2, MDM2, MEFV, MIF, MPO, MTHFR, MYD88, NAT2, NFKB1, NOD1, NOD2, PECAM1, PTGS2, SELE, SERPINE1, SOCS1, SOCS3, STAT1, STAT2, STAT4, TERT, TICAM1, TLR2, TLR3, TLR4, TLR6, TLR9, TP53, TPMT, TRAM1, TSLP, TYK2, TYMS, VEGFA, XRCC1

Chemical, Pharmacological and Biological Annotations


ATC Code:
L03AA02
Brands:
Biocilin; Biofigran; Biofilgran; Endufil; Filatil; Filgen; Gran; Granulokine; Grimatin; Inmunef; Jiexin; Leucogen; Leucostim; Macroleuco; Neukine; Neutromax; Neutroval (Sicor Biotech); Nivestim; Recombicyte; SciLocyte; Tevagastrim; White-C ; Zarxio (Sandoz); Zarzio
Categories:
Immunosuppressive Agents; Antineutropenic Agents; Hematopoietic Agents
KEGG Drug ID:
D03235
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
Filgrastim is used in patients with acute myeloid leukemia receiving induction or consolidation chemotherapy. It is also used in cancer patients receiving bone marrow transplant. In general, filgrastim increases neutrophil counts in order t...
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Pharmacodynamics:
Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Filgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, c...
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Description:
Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analogue manufactured by recombinant DNA technology using a strain of E. coli. It is marketed as the brand name Neupogen by Amgen. Chemically, it...
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Mechanism:
Filgrastim binds to the G-CSF receptor and stimulates the production of neutrophils in the bone marrow. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filg...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org