Rx00109 - Fluoxetine


Name:
Fluoxetine
Rx ID:
Rx00109
Validation Level:
Phenomic Similarity:
0.625
Reference ID:
DB00472
Primary Indications:
Body dysmorphic disorder
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Major depressive disorder; Obsessive Compulsive Disorder; Bulimia Nervosa; panic disorder; premenstrual dysphoric disorde
Pathways:
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics; SIDS Susceptibility Pathways
Drug Interactions:
Acenocoumarol; Almotriptan; Amitriptyline; Amoxapine; Amphetamine; Anisindione; Artemether; Astemizole; Atomoxetine; Benzphetamine; ...
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Food Interactions:
Avoid alcohol. Take with food to reduce irritation and nausea.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00109
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
body dysmorphic disorder Major Depressive Disorder 61 188 17760 73.716 6.47E-86 2.08e-82

Chemical, Pharmacological and Biological Annotations


ATC Code:
N06AB03
Brands:
Adofen (Brainpharma); Animex-On (Laboratorios); Fluoxeren (Menarini); Fontex (Lilly); Ladose (Lilly)
Categories:
Antidepressive Agents, Second-Generation; Serotonin Uptake Inhibitors; Serotonin Agents
ChEBI ID:
5118
PubChem ID:
3386
KEGG Drug ID:
D00823
SMILE:
CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
InChI:
1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
Classification:
Kingdom:
Organic Compounds
Superclass:
Benzenoids
Class:
Benzene and Substituted Derivatives
Subclass:
Phenylpropylamines
Indication:
Labeled indication include: major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and combination treatm...
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Pharmacodynamics:
Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the ...
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Description:
Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity....
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Mechanism:
Metabolized to norfluoxetine, fluoxetine is a selective serotonin-reuptake inhibitor (SSRI), it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT<sub>1A</sub>...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Inhibitor
CYP450 2C19 substrate:
Inhibitor
CYP450 inhibitory promiscuity:
High CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.6048 LD50, mol/kg
hERG inhibition (predictor I):
Strong inhibitor
hERG inhibition (predictor II):
Inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org