Rx00118 - Heparin


Name:
Heparin
Rx ID:
Rx00118
Validation Level:
Phenomic Similarity:
0.534
Reference ID:
DB01109
Primary Indications:
Cystic fibrosis; sickle cell disease
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Venous thrombosis; deep venous thrombosis; pulmonary embolism; thromboembolic disease; atrial fibrillation; consumptive coagulopathies; disseminated intravascular coagulation; peripheral arterial embolism
Drug Interactions:
Acetylsalicylic acid; Aliskiren; Aprotinin; corticotropin-releasing factor; Drospirenone; Drotrecogin alfa; Ginkgo biloba; Ticlopidine; Tobramycin; Treprostinil; ...
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Food Interactions:
Adequate calcium intake is recommended, needs increased with long term use, supplement recommended. Many herbs with anticoagulant properties (e.g. ginger, garlic, ginseng, green tea, evening primrose) may increase the risk of bleeding in patients on anticoagulant therapy such as heparin

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00118
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
sickle cell disease consumptive coagulopathies 76 1477 8875 23.394 1.34E-73 4.31e-70
cystic fibrosis consumptive coagulopathies 11 314 8875 15.927 2.75E-10 8.83e-07

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
SICKLE CELL DISEASE THROMBOEMBOLIC DISEASE 4.53e-35 1231, ABO, ACE, ADRB2, AGT, APOB, APOE, CCL5, CCR5, CYBA, CYP2C19, CYP2D6, EDN1, F13A1, F2, F5, F7, F8, FCGR2A, FGA, FGB, GP1BA, HFE, HLA-DQB1, HLA-DRB1, HMOX1, ICAM1, IL4R, IL6, IL8, ITGA2, ITGB3, LDLR, MBL2, MTHFR, NOS2, NOS3, SELE, SELP, SERPINE1, TGFB1, THBD, TNF, UGT1A1, VCAM1, VEGFA
CYSTIC FIBROSIS THROMBOEMBOLIC DISEASE 1.6e-25 ABCB1, ABO, ACE, ADRB2, AGT, C3, CCL11, CCL2, CCR3, CCR5, CD14, COL1A1, COX8A, CYP2C19, CYP3A4, CYP3A5, EDN1, EDNRA, ESR1, FCGR2A, FUT2, HFE, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, HMOX1, ICAM1, IL10, IL1A, IL1B, IL4, IL4R, IL6, IL8, LPL, LTA, MBL2, NAT2, NFE2L2, NOS2, NOS3, P2RY1, SCNN1A, SERPINA1, TF, TGFB1, TNF, UGT1A1, VCAM1, VDR

Chemical, Pharmacological and Biological Annotations


ATC Code:
C05BA01; C05BA03; S01XA09 S01XA14;
Brands:
Calcilean; Calciparine; Hepalean; Heparin LEO; Liquaemin; Liquemin; Multiparin; Novoheparin
Categories:
Fibrinolytic Agents; Anticoagulants; Heparins
ChEBI ID:
28304
Indication:
Unfractionated heparin is indicated for prophylaxis and treatment of venous thrombosis and its extension, prevention of post-operative deep venous thrombosis and pulmonary embolism and prevention of clotting in arterial and cardiac surgery....
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Pharmacodynamics:
Unfractionated heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from 3000 to 30,000 daltons. Heparin is obtained from li...
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Description:
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly t...
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Mechanism:
Under normal circumstances, antithrombin III (ATIII) inactivates thrombin (factor IIa) and factor Xa. This process occurs at a slow rate. Administered heparin binds reversibly to ATIII and leads to almost instantaneous inactivation of facto...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org