Rx00128 - Immuneglobulin Intravenous (Human)


Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00128
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
adult Primary Immunodeficiency Primary Humoral Immunodeficiency 192 846 2315 395.563 0 0.0
adult severe combined immunodeficiencies Primary Humoral Immunodeficiency 192 846 2315 395.563 0 0.0
adult common variable immunodeficiency common variable immunodeficiency 623 623 623 6476.604 0 0.0
adult X-linked agammaglobulinemia Primary Humoral Immunodeficiency 55 55 2315 1742.948 9.59E-147 3.08e-143
adult Wiskott-Aldrich syndrome Wiskott-Aldrich Syndrome 10 10 10 403492.4 1.08E-49 3.48e-46

Chemical, Pharmacological and Biological Annotations


ATC Code:
J06BA02 J06BA01;
Brands:
Civacir; Flebogamma (Instituto Grifols SA); Gamunex (Talecris Biotherapeutics)
Categories:
Immunologic Factors; Immunosuppressive Agents; Anti-Infective Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders. These indications includes idiopathic thrombocytopenic purpura, Kawasaki disease, hypogammaglobulinemia, B cell chronic lymphocytic leuke...
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Pharmacodynamics:
Used as a replacement therapy in inherited humoral immunodeficiency disorders such as severe combined immunodeficiency syndrome, x-linked agammaglobulinemia, and Wiskott-Aldrich Syndrome. The immunoglobulins target, bind and kill bacterial ...
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Description:
Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion e...
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Mechanism:
IVIg interacts with a number of different components of the immune system, including cytokines, complement, Fc receptors and several cell surface immunocompetent molecules. IVIg also impacts different effector cells of the immune system (B ...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank