Rx00129 - Impiramine


Name:
Impiramine
Rx ID:
Rx00129
Validation Level:
Reference ID:
DB00458
Primary Indications:
Depression
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Small Cell Lung Cancer and Other Neuroendocrine Tumors
Drug Interactions:
Altretamine; Artemether; Atazanavir; Butabarbital; Butalbital; Carbamazepine; Cimetidine; Cisapride; Clonidine; Desvenlafaxine; ...
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Food Interactions:
Avoid alcohol. Avoid excessive quantities of coffee or tea (caffeine). Avoid St.John's Wort. Do not take fibers at the same time. Take with food.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00129
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Chemical, Pharmacological and Biological Annotations


ATC Code:
N06AA03; N06AA06 N06AA02;
Brands:
Antidep (Torrent); Depsonil (Abbott); Depsonil-PM (Abbott); Elamin (Baroda); Fronil (Johnson); Imidol (Tanabe Mitsubishi Pharma); Imipramin Dak (Nycomed); Imiprex (Dumex); Pramin (Incepta)
Categories:
Adrenergic Uptake Inhibitors; Antidepressive Agents, Tricyclic
ChEBI ID:
5881
PubChem ID:
3696
SMILE:
CN(C)CCCN1C2=CC=CC=C2CCC2=CC=CC=C12
InChI:
1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
Classification:
Kingdom:
Organic Compounds
Superclass:
Heterocyclic Compounds
Class:
Benzazepines
Subclass:
Dibenzazepines
Indication:
For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older. May also be used to manage panic disorders, with or without agoraphobia, as a second line agent in ADHD, m...
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Pharmacodynamics:
Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake o...
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Description:
Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In no...
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Mechanism:
Imipramine works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter preventing or reducing the reupt...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
3.0187 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org