Rx00130 - Infliximab


Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00130
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
psoriasis plaque psoriasis 6551 9320 6551 432.932 0 0.0
ulcerative colitis pediatric ulcerative colitis 9520 9520 9520 423.837 0 0.0
rheumatoid arthritis juvenile rheumatoid arthritis 107 7378 352 166.241 8.05E-187 2.58e-183

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
PSORIASIS PSORIATIC ARTHRITIS 1.36e-228 100133214, 100287207, 100287550, 100289398, 100289525, 100294091, 100294095, 100294101, 100294107, 100294112, 100294113, 100294117, 100294118, 100294124, 100294128, 100294129, 100294135, 100294136, 100294140, 100294146, 100294159, 100294164, 100294174, 100294181, 100294187, 100294193, 100294194, 100294203, 100294204, 100294213, 100294223, 100294226, 100294232, 100294237, 100294238, 100294242, 100294244, 100294248, 100294249, 100294254, 100294262, 100294270, 100294273, 100294274, 100294280, 100294281, 100294292, 100294294, 100294302, 100294314, 100294315, 100294320, 100294496, 100294501, 3807, 729792, 730401, ABCF1, ABCG2, ABHD16A, ACE, AFF3, AGER, AGPAT1, AIF1, ATAT1, ATF6B, ATP6V1G2, B3GALT4, BAG6, BAK1, BRD2, BTNL2, C2, C6orf10, C6orf125, C6orf15, C6orf25, C6orf26, C6orf27, C6orf47, C6orf48, CCHCR1, CCL21, CCR2, CCR5, CD28, CDSN, CFB, CLIC1, COL11A2, CSNK2B, CTLA4, CUTA, CYP1A1, CYP2C19, DAXX, DDAH2, DDR1, DDX39B, DHFR, DHX16, DOM3Z, DPCR1, EGF, EGFL8, EHMT2, ERAP1, FBXL19, FCGR2A, FCGR3A, FGF1, FGF2, FKBPL, FLJ16341, FLOT1, GABBR1, GJB2, GNL1, GPANK1, GPSM3, GTF2H4, HCP5, HFE, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-E, HLA-F, HLA-G, HSD17B8, HSPA1A, HSPA1B, HSPA1L, IER3, IFNG, IL10, IL12A, IL12B, IL12RB1, IL13, IL17A, IL17RA, IL1A, IL1B, IL1R1, IL1RN, IL2, IL23A, IL23R, IL28RA, IL36A, IL36RN, IL37, IL4, IL4R, IL6, IL8, IP6K3, IRAK1, ITPR3, KIAA1949, KIF5A, KIFC1, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, LCE1C, LCE3B, LCE3C, LEMD2, LOC100287329, LOC100294307, LSM2, LST1, LTA, LY6G5B, LY6G5C, LY6G6C, LY6G6F, MCCD1, MDC1, MDM2, MEFV, MICA, MICA, MICB, MIR146A, MLN, MOG, MSH5, MTHFR, MUC21, NCRNA00336, NFKB1, NFKBIA, NFKBIL1, NLRP3, NOD2, NOS2, NOTCH4, NRM, OR11A1, OR12D2, OR12D3, OR14J1, OR2B3, OR2H1, OR2H2, OR2J2, OR2J3, OR2W1, OR5V1, PBX2, PFDN6, PHF1, POU5F1, PPARG, PPP1R10, PPP1R11, PPT2, PRR3, PRRC2A, PRRT1, PSMA6, PSMB8, PSMB9, PSORS10, PSORS1C1, PSORS1C2, PSORS2, PSORS4, PSORS5, PSTPIP1, PTPN22, PTTG1, RDBP, REL, RFC1, RGL2, RING1, RNF114, RNF39, RNF5, RPP21, RPS18, RUNX1, RXRB, SFTA2, SKIV2L, SLC22A4, SLC22A5, SLC39A7, SLC44A4, SMARCA4, SOD2, STAT3, STAT4, STK19, SYNGAP1, TAP1, TAP2, TAPBP, TCF19, TNF, TNFAIP3, TNFRSF10A, TNFRSF11A, TNFRSF11B, TNFRSF1A, TNFRSF1B, TNFSF11, TNFSF15, TNIP1, TNXB, TP53, TRAF3IP2, TRIM10, TRIM15, TRIM26, TRIM27, TRIM31, TRIM39, TRIM40, TSC1, TUBB, UBD, VARS, VARS2, VDR, VEGFA, VPS52, WDR46, ZBTB12, ZBTB22, ZBTB9, ZFP57, ZNF311, ZNRD1
RHEUMATOID ARTHRITIS ANKYLOSING SPONDYLITIS 4.6e-100 3807, ABCF1, ACE, ADA, ADRB1, ALPL, ANKH, ANO6, ANTXR2, AR, ASPN, ATG16L1, BMP8A, BTNL2, C11orf30, C1orf106, C1orf81, C4A, C4B, C6orf47, CARD8, CARD9, CCL2, CCL7, CCR6, CD14, CD274, CDKAL1, CNOT3, CNTN5, COL6A1, CTLA4, CYP1A1, CYP2D6, DBP, EDIL3, EEF1DP3, ERAP1, ERAP2, FCGR2B, FCRL3, FCRL4, FCRL5, FOXO1, GC, GCKR, GNL1, GPSM3, GSDMB, HAPLN1, HAVCR2, HHAT, HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-E, HSPA1A, HSPA2, ICOSLG, IKZF3, IL10, IL12B, IL17RA, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1F10, IL1R1, IL1R2, IL1RN, IL23R, IL2RA, IL33, IL36A, IL36B, IL36G, IL36RN, IL37, IL4, IL6, IL6R, IRGM, ITLN1, JAK2, JMY, KDM5A, KIF21B, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DP1, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DP1, KIR3DS1, LAIR2, LRP5, LRRK2, LTA, LTBR, LYRM4, MBL2, MEFV, MICA, MICA, MIR182, MIR196A2, MIR27A, MMP2, MMP3, MSH5, MST1, MSX2, MTHFR, MUC19, NELL1, NFKB1, NFKBIA, NKX2-3, NLRP1, NLRP3, NOD2, NOS3, ORAI1, ORMDL3, PADI4, PBMUCL1, PDCD1, PDCD1LG2, PPARGC1B, PRKRA, PRR3, PSMB8, PSMB9, PSMD7, PSTPIP1, PTGER4, PTPN2, PTPN22, PUS10, RGS6, RUNX3, SCNN1A, SERPINA1, SLC22A23, SNAPC4, SOD2, STAT3, STAT4, TAP1, TAP2, TBKBP1, TGFB1, TIMP1, TLR2, TLR4, TLR8, TLR9, TNAP, TNF, TNFRSF11A, TNFRSF11B, TNFRSF1A, TNFRSF1B, TNFSF11, TNFSF15, TRADD, TRAF5, TRIM31, TSHR, TXNDC5, UGT2B17, VDR, VEGFA, VIPR1, ZNF365, ZPBP2
ULCERATIVE COLITIS RHEUMATOID ARTHRITIS 4.18e-75 3807, 6775066, ABCB1, ACE, ADAD1, AGER, APOE, ATG16L1, BANK1, BSN, BTNL2, C11orf30, C1orf106, CARD8, CARD9, CAT, CCHCR1, CCL11, CCL2, CCL26, CCL3, CCL5, CCND1, CCR5, CCR6, CD14, CD209, CD40, CDKAL1, CEP72, CIITA, CLEC4A, CLIC1, CTLA4, CXCL12, CXCR1, CXCR2, CYP2D6, EHMT2, F13A1, F2, F5, FAS, FCGR2A, FCGR3A, FCGR3B, GCKR, GGH, GPSM3, GSDMB, GSTM1, GSTP1, GSTT1, HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB4, HLA-G, HMOX1, HPRT1, HSPA1L, HSPA2, ICAM1, ICOSLG, IFNG, IL10, IL10RA, IL10RB, IL12B, IL13, IL17A, IL17F, IL18, IL18RAP, IL19, IL1A, IL1B, IL1F10, IL1R1, IL1R2, IL1RL1, IL1RN, IL2, IL20, IL21, IL23R, IL27, IL2RA, IL2RB, IL33, IL4, IL4R, IL6, IL7R, IL8, IRAK3, IRF5, IRGM, ITGAL, ITLN1, ITPA, JAK2, KIAA1109, KIF21B, KIR2DL2, KIR2DL3, LRRK2, LTA, LYRM4, MAP3K1, MBL2, MEFV, MICA, MICB, MIF, MIR146A, MIR196A2, MIR499, MMP1, MMP12, MMP13, MMP2, MMP3, MMP7, MMP9, MST1, MTHFR, MTR, MTRR, MUC19, MYD88, MYO9B, NAT1, NAT2, NELL1, NFKB1, NFKBIL1, NKX2-3, NLRP3, NOD1, NOD2, NOS2, NOS3, NOTCH4, NPSR1, NQO1, NR3C1, OLIG3, ORMDL3, PADI4, PBX2, PDCD1, PPARG, PRDM1, PRRC2A, PTGER4, PTGS2, PTPN11, PTPN2, PTPN22, PUS10, REL, RFC1, RUNX1, RUNX3, SELS, SERPINA1, SFTPD, SLC11A1, SLC22A23, SLC22A4, SLC22A5, SLC39A11, SLC44A4, SOD2, SPP1, STAT3, STAT4, TAB2, TF, TGFB1, TIMP1, TIMP2, TIMP4, TLR1, TLR2, TLR4, TLR6, TLR9, TNF, TNFAIP3, TNFRSF14, TNFRSF1A, TNFRSF1B, TNFRSF6B, TNFSF15, TP53, TPMT, TRAF6, UBE2L3, UCP2, VDR, VTCN1, XRCC1, ZAP70, ZNF365, ZPBP2

Chemical, Pharmacological and Biological Annotations


ATC Code:
L04AB02
Categories:
Antirheumatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Dermatologic Agents; Gastrointestinal Agents; Immunosuppressive Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
To manage the signs and symptoms, as well as to induce and maintain clinical remission in adults with moderate to severe active Crohn's disease or ulcerative colitis. Also used to manage signs and symptoms of rheumatoid arthritis (in conjun...
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Pharmacodynamics:
Infliximab is a chimeric human-murine anti-human tumor necrosis factor (TNF) monoclonal antibody. It binds to tumor necrosis factor alpha (TNFa) and inhibits binding of TNFa with its receptors. This reduces production of pro-inflammatory cy...
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Description:
Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion
Mechanism:
Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with its receptors. Infliximab does not neutralize TNFb (lymphotoxin a), a rela...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org