Rx00131 - Interferon Alfa-2A


Name:
Interferon Alfa-2A
Rx ID:
Rx00131
Validation Level:
Phenomic Similarity:
0.537
Reference ID:
DB05258
Primary Indications:
Recurrent viral infections; chronic hepatitis C; hairy cell leukemia; AIDS; Kaposi's sarcoma; chronic myelogenous leukemia; oral warts; HIV
Orphan Indications:
Esophageal carcinoma; metastatic malignant melanoma
Rare Indications:
Chronic phase, Philadelphia chromosome positive chronic myelogenous leukemia; AIDS; Kaposi's sarcoma
Common Indications:
Hepatitis C
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00131
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
HIV AIDS 11821 11821 11821 341.335 0 0.0
chronic hepatitis C hepatitis C 1601 1601 23010 175.355 0 0.0
chronic myelogenous leukemia chronic phase, Philadelphia chromosome positive chronic myelogenous leukemia 433 433 433 9318.531 0 0.0
AIDS Kaposi's sarcoma 206 11821 432 162.766 0 0.0
oral warts AIDS 1480 12008 11821 42.07 0 0.0
Kaposi's sarcoma AIDS 206 432 11821 162.766 0 0.0

Chemical, Pharmacological and Biological Annotations


ATC Code:
No ATC code annotated in DrugBank
Brand:
Multiferon
Category:
Antineoplastic Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
Investigated for use/treatment in hepatitis (viral, C), leukemia (lymphoid), leukemia (myeloid), leukemia (unspecified), and melanoma.
Pharmacodynamics:
Description:
Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatogra...
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Mechanism:
Natural alpha interferon offers multiple subtypes of interferon which may work together as a 'cocktail-in-one', while recombinant versions only exhibit a single subtype." Viragen offers MultiferonT at a cost which is competitive with recom...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org