Rx00132 - Interferon Alfa-2B (Recombinant)


Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00132
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
malignant melanoma adult malignant melanoma 2544 2544 2544 1586.055 0 0.0
Kaposi's sarcoma adult Kaposi's Sarcoma 432 432 432 9340.102 0 0.0
AIDS adult AIDS 11821 11821 11821 341.335 0 0.0
hairy cell leukemia adult hairy cell leukemia 84 84 84 48034.81 0 0.0

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
HAIRY CELL LEUKEMIA CHRONIC MYELOGENOUS LEUKEMIA 1.61e-08 BRAF, HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRB1, HLA-DRB4, TP53

Chemical, Pharmacological and Biological Annotations


ATC Code:
L03AB05
Category:
Immunosuppressive Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma.
Pharmacodynamics:
Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the...
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Description:
Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles inte...
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Mechanism:
Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which upon dimerization activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The ph...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank