Rx00148 - Mecasermin


Name:
Mecasermin
Rx ID:
Rx00148
Validation Level:
Phenomic Similarity:
0.481
Reference ID:
DB01277
Primary Indications:
Pediatric growth failure; primary IGFD
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Amyotrophic lateral sclerosis; post-poliomyelitis syndrome; growth hormone receptor deficiency; antibody-mediated growth hormone resistance; isolated growth hormone deficiency I; short-bowel syndrome; small bowel resection; congenital dysfunction of the intestines; major burns; myotonic dystrophy
Common Indications:
Juvenile growth failure; severe, primary insulin growth factor-1 deficiency; growth hormone gene deletion
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00148
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
pediatric growth failure juvenile growth failure 5060 5060 5060 797.416 0 0.0

Chemical, Pharmacological and Biological Annotations


ATC Code:
H01AC03
Brand:
Iplex
Categories:
No categories annotated in DrugBank
KEGG Drug ID:
D04870
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For the long-term treatment of growth failure in pediatric patients with Primary IGFD or with GH gene deletion who have developed neutralizing antibodies to GH. It is not indicated to treat Secondary IGFD resulting from GH deficiency, malnu...
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Pharmacodynamics:
Mecasermin is a biosynthetic (recombinant DNA origin) form of human insulin growth factor 1 (IGF-1) designed to replace natural IGF-1 in pediatric patients who are deficient, promoting normalized statural growth. Growth hormones (GH) bind t...
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Description:
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino ac...
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Mechanism:
Mecasermin supplies recombinant-DNA-origin IGF-1, which binds to the Type I IGF-1 receptor. This receptor exerts intra-cellular signaling activity in a number of processes involved in statural growth, including mitogenesis in multiple tissu...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org