Rx00149 - Medroxyprogesterone Acetate

Name:
Medroxyprogesterone Acetate
Rx ID:
Rx00149
Validation Level:
Phenomic Similarity:
0.498
Reference ID:
DB00603
Primary Indications:
Immune thrombocytopenic purpura
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Amenorrhea; abnormal uterine bleeding; endometrial hyperplasia; metastatic endometrial carcinoma; renal carcinoma; endometriosis-associated pain
Pathways:
Estrogen signaling pathway; Estrogen signaling pathway - Homo sapiens (human)
Drug Interactions:
Acenocoumarol; Amobarbital; Anisindione; Aprobarbital; Artemether; Bexarotene; Bosentan; Butabarbital; Butalbital; Butethal; ...
Click to show more...
Food Interactions:
Take with food.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00149
Primary Indication
Secondary Indication

Visualize Chemical Properties

Select x-axis

Select y-axis

Disease prevalence from Electronic Health Records

Click row to show all

Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
immune thrombocytopenic purpura amenorrhea 31 1448 11891 7.265 8.97E-17 2.88e-13

Chemical, Pharmacological and Biological Annotations


ATC Code:
No ATC code annotated in DrugBank
Brand:
Depo-subq provera 104
Categories:
Antineoplastic Agents, Hormonal; Contraceptive Agents, Female; Contraceptive Agents, Male; Contraceptive Agents
ChEBI ID:
6715
KEGG Drug ID:
D00951
SMILE:
[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C
InChI:
1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Lipids
Class:
Steroids and Steroid Derivatives
Subclass:
Gluco/mineralocorticoids, Progestogins and Derivatives
Indication:
Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to ...
Click to show more...
Pharmacodynamics:
Medroxyprogesterone acetate is a synthetic progestin more potent than progesterone.
Description:
Medroxyprogesterone acetate (INN, USAN, BAN), also known as 17α-hydroxy-6α-methylprogesterone acetate, and commonly abbreviated as MPA, is a steroidal progestin, a synthetic variant of the human hormone progesterone. It is used as a contrac...
Click to show more...
Mechanism:
Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gona...
Click to show more...

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
1.8121 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

Knowledge Mapping to Biomedical and Healthcare Ontologies

Click row to see all entries

Term MatchType Ontology ID
MEDROXYPROGESTERONE ACETATE PREF NDFRT N0000146186
ASSOCIATED PREF LOINC LP28580-6
ENDOMETRIAL HYPERPLASIA PREF MESH D004714
METASTATIC ENDOMETRIAL CARCINOMA PREF DOID DOID_8238
ABNORMAL PREF SOPHARM quality.owl#abnormal
UTERINE BLEEDING PREF MEDDRA 10046765