Rx00160 - Midazolam


Name:
Midazolam
Rx ID:
Rx00160
Validation Level:
Phenomic Similarity:
0.776
Reference ID:
DB00683
Primary Indications:
Seizure; epilepsy
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Anxiolytic; anesthesia
Pathways:
Neuroactive ligand-receptor interaction - Homo sapiens (human); Nicotine addiction - Homo sapiens (human); Morphine addiction - Homo sapiens (human); Neurotransmitter Receptor Binding And Downstream T ...Click to show more
Drug Interactions:
Amprenavir; Aprepitant; Atazanavir; Boceprevir; BXT-51072; Carbamazepine; Cimetidine; Clarithromycin; Clobazam; Clozapine; ...
Click to show more...
Food Interactions:
Grapefruit juice slows the product's absorption and significantly increases its bioavailability.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00160
Primary Indication
Secondary Indication

Visualize Chemical Properties

Select x-axis

Select y-axis

Chemical, Pharmacological and Biological Annotations


ATC Code:
N05CD08
Brands:
Anquil (General Pharma); Benzosed (Pharmaceutical); Dalam (Richmond); Damizol (Specifar); Demizolam (Dem Ilaç); Doricum (Roche); Dormicum (Roche); Dormid (Scott); Dormipron (Chalver); Dormire (Cristália); Dormitol (Square); Dormixal (Demo); Dormonid (Roche); Drimnorth (Northia); Epistatus (IFET); Flormidal (Galenika); Fulsed (Ranbaxy); Fulsed Injection (Terapia); Garen (Bio-Pharma); Gobbizolam (Gobbi); Hipnazolam (EMS); Hipnoz (Pharos); Hypnofast (Incepta); Hypnovel (Roche); Ipnovel (Roche); Nocturna (Lafi); Setam (Rimsa); Talentum (Fisiopharma); Terap (Sanitas); Versed (Roche)
Categories:
Anti-Anxiety Agents; Hypnotics and Sedatives; Anesthetics, Intravenous; Adjuvants, Anesthesia; GABA Modulators
PubChem ID:
4192
KEGG Drug ID:
D00550
SMILE:
CC1=NC=C2CN=C(C3=CC=CC=C3F)C3=C(C=CC(Cl)=C3)N12
InChI:
1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
Classification:
Kingdom:
Organic Compounds
Superclass:
Heterocyclic Compounds
Class:
Benzodiazepines
Subclass:
Indication:
The midazolam injection is indicated for preoperative sedation/anziolysis/amnesia. It is also an agent for sedation/anziolysis/amnesia prior to or during diagnostic, therapeutic, or endoscopic procedures. Midazolam can also be given intrave...
Click to show more...
Pharmacodynamics:
Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. Pharmacodynamic properties of midazolam and its metabolites, which are similar to those of other benzodiazepines, include sedative, anxiolytic, amnesic and ...
Click to show more...
Description:
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardi...
Click to show more...
Mechanism:
It is thought that the actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the brain. Benzodiazepines in...
Click to show more...

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Inhibitor
CYP450 inhibitory promiscuity:
High CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
3.1488 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org