Rx00175 - Nitric Oxide


Name:
Nitric Oxide
Rx ID:
Rx00175
Validation Level:
Phenomic Similarity:
0.547
Reference ID:
DB00435
Primary Indications:
Angina pectoris
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Adult acute respiratory distress syndrome; premature neonatal chronic lung disease; sarcoidosis; sickle cell vaso-occlusive crisis; pain crises
Common Indications:
Neonatal hypoxic respiratory failure; neonatal pulmonary hypertension
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00175
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
ANGINA PECTORIS SARCOIDOSIS 7.23e-24 ABCB1, ACE, ACE2, AGTR1, ARHGAP9, C4B, CCL2, CD14, CD40, CHI3L1, CMA1, CTLA4, CYBA, EDN1, HLA-DRB1, ICAM1, IFNG, IL10, IL18, IL1A, IL1B, IL1RN, IL6, KDR, MIF, MMP1, MMP9, NOS2, NOS3, PPARG, PTGS2, TGFB1, TLR4, TNF, VDR, VEGFA

Chemical, Pharmacological and Biological Annotations


ATC Code:
R07AX01
Categories:
Bronchodilator Agents; Endothelium-Dependent Relaxing Factors; Free Radical Scavengers; Neurotransmitter Agents
ChEBI ID:
16480
PubChem ID:
145068
KEGG Drug ID:
D00074
SMILE:
[N]=O
InChI:
1S/NO/c1-2
Classification:
Kingdom:
Inorganic Compounds
Superclass:
Homogeneous Non-metal Compounds
Class:
Other Non-metal Organides
Subclass:
Other Non-metal Oxides
Indication:
For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
Pharmacodynamics:
Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia, sepsis, hyaline membrane disease, congenit...
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Description:
Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It i...
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Mechanism:
Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanos...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Non-substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
AMES toxic
Carcinogenicity:
Carcinogens
Biodegradation:
Ready biodegradable
Rat acute toxicity:
2.5108 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org