Rx00180 - Oxandrolone


Name:
Oxandrolone
Rx ID:
Rx00180
Validation Level:
Phenomic Similarity:
0.487
Reference ID:
DB00621
Primary Indications:
Turner's syndrome; growth delay; puberty delay; Duchenne's muscular dystrophy; Becker's muscular dystrophy; HIV-wasting syndrome; Acquired Immunodeficiency Syndrome; acute alcoholic hepatitis; moderate protein calorie malnutrition
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Bone pain; osteoporosis; low weight
Drug Interactions:
Warfarin;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00180
Primary Indication
Secondary Indication

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
HIV-wasting syndrome osteoporosis 568 11821 31300 6.194 8.96E-240 2.88e-236
acquired immunodeficiency syndrome osteoporosis 568 11821 31300 6.194 8.96E-240 2.88e-236
growth delay low weight 71 3494 2200 37.269 7.94E-83 2.55e-79
puberty delay low weight 23 305 2200 138.306 1.07E-40 3.44e-37
acute alcoholic hepatitis osteoporosis 48 1258 31300 4.919 3.32E-18 1.07e-14
Turner's syndrome osteoporosis 21 206 31300 13.141 2.05E-16 6.57e-13
Duchenne muscular dystrophy osteoporosis 22 340 31300 8.341 2.36E-13 7.56e-10
Becker's muscular dystrophy osteoporosis 22 340 31300 8.341 2.36E-13 7.56e-10

Chemical, Pharmacological and Biological Annotations


ATC Code:
A14AA08
Brands:
Anavar (Pfizer Inc.); Oxandrin (Savient Pharmaceuticals); Xtendrol (Atlantis)
Categories:
Anabolic Agents; Androgens
ChEBI ID:
7820
PubChem ID:
5878
KEGG Drug ID:
D00462
SMILE:
[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)OC[C@]12C
InChI:
1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Lipids
Class:
Steroids and Steroid Derivatives
Subclass:
Ketosteroids
Indication:
Use to promote weight gain after weight loss following extensive surgery.
Pharmacodynamics:
Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reaso...
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Description:
A synthetic hormone with anabolic and androgenic properties. [PubChem]
Mechanism:
Oxandrolones interact with androgen receptors in target tissues.

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
1.5177 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org