Rx00190 - Pentostatin


Name:
Pentostatin
Rx ID:
Rx00190
Validation Level:
Phenomic Similarity:
0.485
Reference ID:
DB00552
Primary Indications:
Hairy cell leukemia
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Chronic lymphocytic leukemia; cutaneous T-cell lymphoma; peripheral T-cell lymphoma
Common Indications:
Adult alpha-interferon-refractory hairy cell leukemia; anemia; neutropenia; thrombocytopenia
Drug Interactions:
Cyclophosphamide; Fludarabine; Pegademase bovine Trastuzumab;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00190
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
hairy cell leukemia anemia 31 84 109590 13.588 1.51E-22 4.84e-19

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
HAIRY CELL LEUKEMIA THROMBOCYTOPENIA 5.38e-06 HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRB1, HLA-DRB4, TP53

Chemical, Pharmacological and Biological Annotations


ATC Code:
L01XX08
Categories:
Antineoplastic Agents; Adenosine Deaminase Inhibitors; Antibiotics
PubChem ID:
439693
KEGG Drug ID:
D00155
SMILE:
OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2=C1N=CNC[C@H]2O
InChI:
1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Organooxygen Compounds
Class:
Carbohydrates and Carbohydrate Conjugates
Subclass:
Glycosyl Compounds
Indication:
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Pharmacodynamics:
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the buil...
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Description:
A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppres...
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Mechanism:
Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher act...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
-
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.2716 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org