Rx00198 - Primaquine


Name:
Primaquine
Rx ID:
Rx00198
Validation Level:
Phenomic Similarity:
0.607
Reference ID:
DB01087
Primary Indications:
Vivax malaria
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Pneumocystis carinii pneumonia; AIDS
Common Indications:
Vivex malaria
Drug Interactions:
Artemether; Lumefantrine; Tacrine; Thiothixene Tizanidine;
Food Interactions:
Take with food to decrease dyspepsia.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00198
Primary Indication
Secondary Indication

Visualize Chemical Properties

Select x-axis

Select y-axis

Disease prevalence from Electronic Health Records

Click row to show all

Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
vivax malaria malaria 6 6 167 24161.222 5.26E-24 1.69e-20

Chemical, Pharmacological and Biological Annotations


ATC Code:
P01BA03
Brands:
Neo-Quipenyl; Primachin
Category:
Antimalarials
ChEBI ID:
8405
PubChem ID:
4908
SMILE:
COC1=CC(NC(C)CCCN)=C2N=CC=CC2=C1
InChI:
1S/C15H21N3O/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14/h4,6,8-11,18H,3,5,7,16H2,1-2H3
Classification:
Kingdom:
Organic Compounds
Superclass:
Heterocyclic Compounds
Class:
Quinolines and Derivatives
Subclass:
Aminoquinolines and Derivatives
Indication:
For the treatment of malaria.
Pharmacodynamics:
Primaquine is an antimalarial agent and is the essential co-drug with chloroquine in treating all cases of malaria. In the blood, malaria parasites break down a part of the red blood cells known as haemoglobin. When this happens haemoglobin...
Click to show more...
Description:
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those ...
Click to show more...
Mechanism:
Primaquine's mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may...
Click to show more...

Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
-
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Inhibitor
CYP450 2C19 substrate:
Inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.4474 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Inhibitor

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org