Rx00200 - Progesterone


Name:
Progesterone
Rx ID:
Rx00200
Validation Level:
Phenomic Similarity:
0.693
Reference ID:
DB00396
Primary Indications:
In vitro fertilization; embryo transfer; closed-head traumatic brain injury
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Endometrial hyperplasia; amenorrhea; abnormal uterine bleeding; hormonal imbalance; embryo implantation; infertility
Pathways:
Estrogen signaling pathway; Estrogen signaling pathway - Homo sapiens (human)
Drug Interactions:
Topotecan;
Food Interactions:
Avoid alcohol. Avoid excessive quantities of coffee or tea (Caffeine). Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin. Take at the same time everyday. Take with food.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00200
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
closed-head traumatic brain injury amenorrhea 56 7675 11891 2.476 2.91E-09 9.35e-06

Chemical, Pharmacological and Biological Annotations


ATC Code:
G03AC06; G03DA02; G03DA03; G03DA04 L02AB02;
Brands:
Agolutin (Biotika); Cyclogest (Actavis); Gesterol; Gestone (Nordic Pharma); Progestasert; Progestogel (Besins); Qi Ning (Aisheng Pharmaceutical); Relantan (Aversi); Susten (Sun Pharma); Utrogestan (Besins); Utrogestran (Faran Laboratories); Utrovin (Bestochem); Vasclor (Verisfield)
Categories:
Progestins; Contraceptive Agents
ChEBI ID:
17026
PubChem ID:
5994
KEGG Drug ID:
D00066
SMILE:
[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
InChI:
1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Lipids
Class:
Steroids and Steroid Derivatives
Subclass:
Gluco/mineralocorticoids, Progestogins and Derivatives
Indication:
For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of th...
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Pharmacodynamics:
Progesterone is a naturally occuring progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then...
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Description:
The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the dev...
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Mechanism:
Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. On...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
1.8041 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

Contact Us:
Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org