Rx00201 - Protein C Concentrate


Name:
Protein C Concentrate
Rx ID:
Rx00201
Validation Level:
Phenomic Similarity:
0.537
Reference ID:
FDA:0140
Primary Indications:
Severe congenital protein C deficiency; venous thrombosis; purpura fulminans
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Congenital protein C deficiency; acquired protein C deficiency; warfarin-induced skin necrosis during oral anticoagulation; purpura fulminans; meningococcemia
Common Indications:
Protein C deficiency; venous thrombosis; purpura fulminans
Drug Interactions:
No annotated drug interactions in DrugBank.
Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00201
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
severe congenital protein C deficiency acquired protein C deficiency 3804 3804 3804 1060.706 0 0.0
venous thrombosis warfarin-induced skin necrosis during oral anticoagulation 285 9840 1081 108.108 0 0.0
purpura fulminans venous thrombosis 142 1307 9840 44.551 1.65E-172 5.29e-169

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
VENOUS THROMBOSIS PROTEIN C DEFICIENCY 3.08e-12 ACE, CADM1, F2, F5, ITGB3, MTHFR, PAFAH1B2, PROC, PROCR, PROS1, SERPINC1, SERPINE1

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org