Rx00203 - Quinine


Name:
Quinine
Rx ID:
Rx00203
Validation Level:
Phenomic Similarity:
0.87
Reference ID:
DB00468
Primary Indications:
Malaria; leg cramps
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Malaria
Common Indications:
Uncomplicated Plasmodium falciparum malaria
Drug Interactions:
Acenocoumarol; Anisindione; Artemether; Astemizole; Atomoxetine; Atracurium; Dicoumarol; Digitoxin; Digoxin; Lumefantrine; ...
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Food Interactions:
Take with food to reduce irritation.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00203
Primary Indication
Secondary Indication

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Chemical, Pharmacological and Biological Annotations


ATC Code:
M09AA01 P01BC01;
Brands:
Cinkona (Ipca); Jasoquin (Jayson); QSM (Leben); Quinlup (Lupin); Qutil (Little Greave); Sulquin (Saga)
Categories:
Antimalarials; Analgesics, Non-Narcotic; Muscle Relaxants, Central
ChEBI ID:
15854
SMILE:
[H][C@]1(C[C@@H]2CC[N@]1C[C@@H]2C=C)[C@H](O)C1=CC=NC2=CC=C(OC)C=C12
InChI:
1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Alkaloids and Derivatives
Class:
Cinchona Alkaloids
Subclass:
Indication:
For the treatment of malaria and leg cramps
Pharmacodynamics:
Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. mal...
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Description:
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic ...
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Mechanism:
The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the drugs interfere with the parasite's ability to break down and digest hemoglobin. Conseque...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Inhibitor
Renal organic cation transporter:
Inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
3.0596 LD50, mol/kg
hERG inhibition (predictor I):
Strong inhibitor
hERG inhibition (predictor II):
Inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org