Rx00213 - Ropiniorle


Name:
Ropiniorle
Rx ID:
Rx00213
Validation Level:
Phenomic Similarity:
0.535
Reference ID:
DB00268
Primary Indications:
Hypertension
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Parkinson's disease; Idiopathic restless leg syndrome
Pathways:
Monoamine GPCRs; Amine ligand-binding receptors; GPCRs, Class A Rhodopsin-like; Nicotine Activity on Dopaminergic Neurons; Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics; Hypothetical Networ ...Click to show more
Drug Interactions:
Ciprofloxacin; Dihydrocodeine; Fluvoxamine; Paliperidone; Thiothixene; Ziprasidone Zuclopenthixol;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00213
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
Hypertension Parkinson's disease 3388 276326 7763 6.373 0 0.0

Chemical, Pharmacological and Biological Annotations


ATC Code:
N04BC04
Brands:
Adartrel; ReQuip CR (GlaxoSmithKline); Ronirol
Categories:
Antiparkinson Agents; Dopamine Agonists; Antidyskinetics
ChEBI ID:
8888
PubChem ID:
5095
SMILE:
CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1
InChI:
1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
Classification:
Kingdom:
Organic Compounds
Superclass:
Heterocyclic Compounds
Class:
Indoles and Derivatives
Subclass:
Indolines
Indication:
For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.
Pharmacodynamics:
Ropinirole is a nonergot dopamine agonist with high relative <i>in vitro</i> specificity and full intrinsic activity at the D<sub>2</sub> subfamily of dopamine receptors, binding with higher affinity to D<sub>3</sub> than to D<sub>2</sub> o...
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Description:
Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson's disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of...
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Mechanism:
Ropinirole binds the dopamine receptors D<sub>3</sub> and D<sub>2</sub>. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is believed to be related to its ability to stimulate thes...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
2.6400 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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