Rx00220 - Somatropin


Name:
Somatropin
Rx ID:
Rx00220
Validation Level:
Phenomic Similarity:
0.508
Reference ID:
DB00052
Primary Indications:
Juvenile growth failure; adult growth failure; adult growth hormone deficiency; juvenile growth hormone deficiency; chronic kidney failure; Noonan syndrome; Turner syndrome; Prader-Willi syndrome; short stature at birth with no catch-up growth; AIDS; short bowel syndrome
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Female infertility; hypogonadotropic hypogonadism; bilateral tubal occlusion; unexplained infertility, in vivo fertilization; in vitro fertilization; severe burn; HIV-associated adipose redistribution syndrome; pediatric short stature; pediatric short stature homeobox-containing gene deficiency
Common Indications:
Juvenile endogenous growth hormone deficiency; juvenile growth failure; short stature; Noonan syndrome; pediatric growth failure; pediatric Prader-Willi syndrome; Turner syndrome; chronic renal insufficency; epiphyseal closure; adult growth hormone deficiency; short bowel syndrome
Drug Interactions:
Acarbose; Chlorpropamide; Exenatide; Gliclazide; Glimepiride; Glipizide; Glyburide; Insulin Aspart; Insulin Detemir; Insulin Glargine; ...
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Food Interactions:
No annotated food interactions in DrugBank.

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00220
Primary Indication
Secondary Indication

Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
Noonan syndrome pediatric growth failure 318 1129 5060 224.604 0 0.0
chronic kidney failure HIV-associated adipose redistribution syndrome 572 11565 11821 16.882 0 0.0
juvenile growth failure pediatric growth failure 5060 5060 5060 797.416 0 0.0
AIDS HIV-associated adipose redistribution syndrome 11821 11821 11821 341.335 0 0.0
adult growth hormone deficiency pediatric growth failure 734 1051 5060 556.901 0 0.0
juvenile growth hormone deficiency adult growth hormone deficiency 1051 1051 1051 3839.128 0 0.0
short stature at birth with no catch-up growth pediatric growth failure 222 3494 5060 50.666 2.53E-281 8.11e-278
adult growth failure pediatric growth failure 222 3494 5060 50.666 2.53E-281 8.11e-278
Turner syndrome pediatric growth failure 36 206 5060 139.354 3.34E-62 1.07e-58

Shared Genetic Architectures of Disease Pairs

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Disease A Disease B Adjusted P-Value Shared Gene IDs
CHRONIC KIDNEY FAILURE FEMALE INFERTILITY 2.26e-18 ADM, ADRB2, ADRB3, BHMT, BRCA1, BRCA2, C10orf55, CBS, CCR5, COMT, CPB2, CTLA4, CYP17A1, CYP19A1, CYP1A1, CYP1A2, DRD2, ESR1, ESR2, F13A1, F13B, F2, F5, FGA, FGB, FGG, GSTM1, GSTP1, GSTT1, HLA-DQA1, HLA-DQB1, HLA-G, IFNG, IL10, IL1B, IL1RN, IL6, ITGB3, MBL2, MDM2, MTHFD1, MTHFR, MTR, MTRR, NFKB1, NOS3, NR3C1, PGR, PLAT, PPARG, RAD54B, SCARB1, SERPINE1, SHBG, SLC19A1, TCF7L2, TCN2, TGFB1, TLR2, TLR4, TNF, TP53, TYK2, VDR, VEGFA, WNT4

Chemical, Pharmacological and Biological Annotations


ATC Code:
H01AC01
Brands:
BioTropin (Biotech General); NutropinAQ (Genentech Inc.); Protropin (Genentech Inc.)
Category:
Hormone Replacement Agents
Classification:
Kingdom:
Organic Compounds
Superclass:
Organic Acids
Class:
Carboxylic Acids and Derivatives
Subclass:
Amino Acids, Peptides, and Analogues
Indication:
For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss
Pharmacodynamics:
Used in the treatment of dwarfism and growth failure, growth hormone (hGH) stimulates skeletal growth in pediatric patients with growth failure due to a lack of adequate secretion of endogenous GH. Skeletal growth is accomplished at the epi...
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Description:
Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli
Mechanism:
hGH binds to the human growth hormone receptor (GHR). Upon binding, hGH causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activat...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Not Available from DrugBank


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Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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Manhattan, New York City, NY
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