Rx00230 - Testosterone


Name:
Testosterone
Rx ID:
Rx00230
Validation Level:
Phenomic Similarity:
0.567
Reference ID:
DB00624
Primary Indications:
Vulvar dystrophies; juvenile constitutional delay of growth; juvenile constitutional delay of puberty; testosterone replacement; HIV
Orphan Indications:
No annotated orphan indications.
Rare Indications:
No annotated rare indications.
Common Indications:
Testosterone deficiency; testosterone absence; primary hypogonadism; testical failure; cryptorchidism; bilateral torsion; orchitis; vanishing testis syndrome; orchiectomy; Klinefelter's syndrome; toxic damange; hypogonadotropic hypogonadism; idiopathic gonadotropin deficiency; luteinizing hormone-releasing hormone deficiency; pituitary-hypothalamic injury
Drug Interactions:
Acenocoumarol; Anisindione; Cyclosporine; Dicoumarol; Docetaxel Warfarin;
Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00230
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
testosterone replacement testosterone deficiency 4402 4402 4402 916.612 0 0.0
juvenile constitutional delay of growth idiopathic gonadotropin deficiency 734 5060 1051 556.901 0 0.0
HIV testosterone deficiency 544 11821 4402 42.182 0 0.0
juvenile constitutional delay of puberty idiopathic gonadotropin deficiency 46 305 1051 579.016 3.38E-107 1.08e-103

Chemical, Pharmacological and Biological Annotations


ATC Code:
G03BA02; G03BA03 G03EK01;
Brands:
Andriol (Merck); Andronate 100; Andronate 200; Andropatch (GlaxoSmithKline); Andropository 200; Andryl 200; Bio-T-Gel (BioSante Pharmaceuticals, Inc. and Teva Pharmaceuticals USA, Inc.); Intrinsa (Procter & Gamble); Livensa (Procter & Gamble); Nebido (Bayer); Sustanon (Organon); Testamone 100; Testaqua IM; Testoderm; Testoderm TTS; Testogel (Bayer); Testolin; Testopatch (Pierre Fabre); Testopel Pellets; Testrin-P.A; Testro AQ; Virormone (Nordic Pharma)
Category:
Androgens
ChEBI ID:
17347
PubChem ID:
6013
KEGG Drug ID:
D00075
SMILE:
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
InChI:
1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Lipids
Class:
Steroids and Steroid Derivatives
Subclass:
Androgens and Derivatives
Indication:
To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopa...
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Pharmacodynamics:
Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted from the testes of males. In females, it is produced in the ovaries, adrenal glands and by conversion of adrostenedione in the periphery. It is th...
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Description:
Testosterone is a steroid sex hormone found in both men and women. In men, testosterone is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatoge...
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Mechanism:
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free ...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
+
Blood Brain Barrier:
+
Caco-2 permeable:
+
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
1.6259 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

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Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.


Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1498
Manhattan, New York City, NY
repurposedb@dudleylab.org