Rx00236 - Tobramycin

Name:
Tobramycin
Rx ID:
Rx00236
Validation Level:
Phenomic Similarity:
0.583
Reference ID:
DB00684
Primary Indications:
Pseudomonas aeruginosa lung infection
Orphan Indications:
No annotated orphan indications.
Rare Indications:
Bronchiectasis
Common Indications:
Cystic fibrosis
Drug Interactions:
Acetazolamide; Amphotericin B; Atracurium; Benazepril; Bumetanide; Candesartan; Captopril; Cefamandole; Cefapirin; Cefazolin; ...
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Food Interactions:
No annotated food interactions in DrugBank.

Interactive 3D Model

Interactive Drug Target Network

Interactive Bipartite Drug Repurposing Graph

Rx00236
Primary Indication
Secondary Indication

Visualize Chemical Properties

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Disease prevalence from Electronic Health Records

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Disease A Disease B A∩B A∩¬B B∩¬A Odds-Ratio P-Value Adjusted P-Value
pseudomonas aeruginosa lung infection bronchiectasis 114 1806 3071 82.936 1.42E-169 4.57e-166

Chemical, Pharmacological and Biological Annotations


ATC Code:
J01GB01 S01AA12;
Brands:
Aktob (Akorn); Alveoterol (Tetrafarm); Amgy (Kobec); Bactob (Solitaire); Belbarmicina (Quimica Luar); Bideon Biotic (Fecofar); Bioptic (Bausch & Lomb); Bramitob (Torrex); Gernebcin (Infectopharm); Nebcin (Lilly); Obracin (EuroCept); Tobracin (Opso Saline); Tobramaxin (Alcon)
Categories:
Anti-Bacterial Agents; Aminoglycosides
ChEBI ID:
28864
PubChem ID:
36294
KEGG Drug ID:
D00063
SMILE:
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
InChI:
1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
Classification:
Kingdom:
Organic Compounds
Superclass:
Organooxygen Compounds
Class:
Carbohydrates and Carbohydrate Conjugates
Subclass:
Amino Sugars
Indication:
For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.
Pharmacodynamics:
Tobramycin, an aminoglycoside antibiotic obtained from cultures of <i>Streptomyces tenebrarius</i>, is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumoni...
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Description:
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by ...
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Mechanism:
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active tra...
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Adsorption, Distribution, Metabolism, Excretion and Toxicity


Human Intestinal Absorption:
-
Blood Brain Barrier:
-
Caco-2 permeable:
-
P-glycoprotein substrate:
Substrate
P-glycoprotein inhibitor I:
Non-inhibitor
P-glycoprotein inhibitor II:
Non-inhibitor
Renal organic cation transporter:
Non-inhibitor
CYP450 2C9 substrate:
Non-inhibitor
CYP450 2D6 substrate:
Non-inhibitor
CYP450 2C19 substrate:
Non-inhibitor
CYP450 inhibitory promiscuity:
Low CYP Inhibitory Promiscuity
Ames test:
Non AMES toxic
Carcinogenicity:
Non-carcinogens
Biodegradation:
Not ready biodegradable
Rat acute toxicity:
1.7638 LD50, mol/kg
hERG inhibition (predictor I):
Weak inhibitor
hERG inhibition (predictor II):
Non-inhibitor

Knowledge Mapping to Biomedical and Healthcare Ontologies

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Term MatchType Ontology ID
LUNG INFECTION PREF MEDDRA 10061229
TOBRAMYCIN PREF RH-MESH mesh.owl#D014031
BRONCHIECTASIS PREF BHO BPO.owl#bronchiectasis
PSEUDOMONAS AERUGINOSA PREF SNMI L-23401
CYSTIC FIBROSIS PREF MESH D003550

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PDB SDF Ontologies Network

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 Please contact us if you have questions or comments about RepurposeDB. You can also contact us if you need help in submitting your drug repositioning investigation to RepurposeDB.
Dudley Laboratory
Department of Genetics and Genomic Sciences
Icahn Institute for Genomics and Multiscale Biology
Icahn School of Medicine at Mount Sinai
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Manhattan, New York City, NY
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© 2016 Joel T Dudley Laboratory Research | © 2016 Icahn School of Medicine at Mount Sinai